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Cyp2c70 Gene Detail
Summary
  • Symbol
    Cyp2c70
  • Name
    cytochrome P450, family 2, subfamily c, polypeptide 70
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385878
    NCBI Gene: 226105
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:40141805-40175730 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 34.24 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1162 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385878
 protein coding gene Chr19:40141797-40175777 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025109
 protein coding gene Chr19:39341770-39384240 (-)
A/J MGP_AJ_G0025086
 protein coding gene Chr19:37419981-37454738 (-)
AKR/J MGP_AKRJ_G0025054
 protein coding gene Chr19:38690637-38729006 (-)
BALB/cJ MGP_BALBcJ_G0025080
 protein coding gene Chr19:37502765-37537698 (-)
C3H/HeJ MGP_C3HHeJ_G0024840
 protein coding gene Chr19:38816855-38858789 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025524
 protein coding gene Chr19:40413157-40452142 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022937
 protein coding gene Chr19:36845479-36876316 (-)
CAST/EiJ MGP_CASTEiJ_G0024305
 protein coding gene Chr19:38469169-38504332 (-)
CBA/J MGP_CBAJ_G0024820
 protein coding gene Chr19:42387551-42424711 (-)
DBA/2J MGP_DBA2J_G0024952
 protein coding gene Chr19:37312071-37344688 (-)
FVB/NJ MGP_FVBNJ_G0024913
 protein coding gene Chr19:37077630-37112689 (-)
LP/J MGP_LPJ_G0025038
 protein coding gene Chr19:39361946-39411593 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024944
 protein coding gene Chr19:42105816-42153394 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025581
 protein coding gene Chr19:38729954-38763702 (-)
PWK/PhJ MGP_PWKPhJ_G0024055
 protein coding gene Chr19:37168122-37202461 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023858
 protein coding gene Chr19:37489639-37524669 (-)
WSB/EiJ MGP_WSBEiJ_G0024375
 protein coding gene Chr19:38889853-38924654 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit cholestatic liver injury, with an increase in liver bile acid content enriched in chenodeoxycholic acid but devoid of protective hydrophilic muricholic acids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    95
  • cDNA Data
    104
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226105 NCBI Gene Model | MGI Sequence Detail 33926 C57BL/6J ±  kb
    transcript NM_145499 RefSeq | MGI Sequence Detail 1709 C57BL/6  
    polypeptide Q91W64 UniProt | EBI | MGI Sequence Detail 489 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 104

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
    • Latest
      J:341617 Zhang J, et al., CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid. FASEB J. 2023 Jul;37(7):e23009
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory