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Picalm Gene Detail
Summary
  • Symbol
    Picalm
  • Name
    phosphatidylinositol binding clathrin assembly protein
  • Synonyms
    fit-1, fit1, MGC:19382, MGC:36413, MGC:36616
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385902
    NCBI Gene: 233489
  • Alliance
    gene page
  • Transcription Start Sites
    50 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:89778711-89858655 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 50.47 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1686 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385902
 protein coding gene Chr7:89778711-89862673 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032503
 protein coding gene Chr7:92541489-92623115 (+)
A/J MGP_AJ_G0032477
 protein coding gene Chr7:90316553-90397901 (+)
AKR/J MGP_AKRJ_G0032413
 protein coding gene Chr7:92415467-92511983 (+)
BALB/cJ MGP_BALBcJ_G0032488
 protein coding gene Chr7:89963031-90043081 (+)
C3H/HeJ MGP_C3HHeJ_G0032203
 protein coding gene Chr7:92816270-92899541 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032986
 protein coding gene Chr7:96155684-96241018 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029981
 protein coding gene Chr7:93208195-93291086 (+)
CAST/EiJ MGP_CASTEiJ_G0031530
 protein coding gene Chr7:84250215-84331347 (+)
CBA/J MGP_CBAJ_G0032170
 protein coding gene Chr7:99359834-99447041 (+)
DBA/2J MGP_DBA2J_G0032322
 protein coding gene Chr7:88741887-88823737 (+)
FVB/NJ MGP_FVBNJ_G0032278
 protein coding gene Chr7:88614875-88697316 (+)
LP/J MGP_LPJ_G0032411
 protein coding gene Chr7:93788000-93882509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032312
 protein coding gene Chr7:100355244-100455403 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033008
 protein coding gene Chr7:91705641-91786221 (+)
PWK/PhJ MGP_PWKPhJ_G0031248
 protein coding gene Chr7:81781664-81866083 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031091
 protein coding gene Chr7:79027898-79120351 (+)
WSB/EiJ MGP_WSBEiJ_G0031647
 protein coding gene Chr7:92378682-92460594 (+)



Homology
more
  • Human Ortholog
    PICALM, phosphatidylinositol binding clathrin assembly protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PICALM, phosphatidylinositol binding clathrin assembly protein
  • Synonyms
    CALM, CLTH, LAP
  • Links
    NCBI Gene ID: 8301
    neXtProt AC: NX_Q13492
    UniProt: Q13492

  • Chr Location
    11q14.2; chr11:85957175-86069882 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PICALM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 8 alleles in 7 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for different ENU-induced mutations or knock-out alleles are small, runted and display anemia of variable severity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    130
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    15
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233489 NCBI Gene Model | MGI Sequence Detail 79945 C57BL/6J ±  kb
    transcript NM_001420463 RefSeq | MGI Sequence Detail 4232 ZRU/MplStud  
    polypeptide Q7M6Y3 UniProt | EBI | MGI Sequence Detail 660 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 14
      Primer pair 3
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9805, MGD-MRK-9806, MGI:95538
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 13
      Phenotypes 47
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:344571 Kisler K, et al., Anti-malaria drug artesunate prevents development of amyloid-beta pathology in mice by upregulating PICALM at the blood-brain barrier. Mol Neurodegener. 2023 Jan 27;18(1):7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory