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Gabbr2 Gene Detail
Summary
  • Symbol
    Gabbr2
  • Name
    gamma-aminobutyric acid type B receptor subunit 2
  • Synonyms
    Gababr2, GB2, Gpr51, LOC242425
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386030
    NCBI Gene: 242425
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:46662318-46991714 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 25.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9029 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386030
 protein coding gene Chr4:46662305-46991873 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028263
 protein coding gene Chr4:44984609-45349877 (-)
A/J MGP_AJ_G0028222
 protein coding gene Chr4:43319557-43650854 (-)
AKR/J MGP_AKRJ_G0028172
 protein coding gene Chr4:44395913-44742692 (-)
BALB/cJ MGP_BALBcJ_G0028242
 protein coding gene Chr4:43431665-43771022 (-)
C3H/HeJ MGP_C3HHeJ_G0027963
 protein coding gene Chr4:44991495-45338254 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028683
 protein coding gene Chr4:46659548-47017570 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025992
 protein coding gene Chr4:40698768-41027812 (-)
CAST/EiJ MGP_CASTEiJ_G0027402
 protein coding gene Chr4:44553641-44914130 (-)
CBA/J MGP_CBAJ_G0027929
 protein coding gene Chr4:48136146-48495901 (-)
DBA/2J MGP_DBA2J_G0028079
 protein coding gene Chr4:43219166-43555083 (-)
FVB/NJ MGP_FVBNJ_G0028046
 protein coding gene Chr4:42476113-42817043 (-)
LP/J MGP_LPJ_G0028178
 protein coding gene Chr4:45040855-45400528 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028070
 protein coding gene Chr4:51202482-51556912 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028718
 protein coding gene Chr4:44616141-44966850 (-)
PWK/PhJ MGP_PWKPhJ_G0027127
 protein coding gene Chr4:43319143-43658432 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026955
 protein coding gene Chr4:44114412-44471767 (-)
WSB/EiJ MGP_WSBEiJ_G0027480
 protein coding gene Chr4:44528235-44887523 (-)



Homology
more
  • Human Ortholog
    GABBR2, gamma-aminobutyric acid type B receptor subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABBR2, gamma-aminobutyric acid type B receptor subunit 2
  • Synonyms
    DEE59, EIEE59, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, NDPLHS
  • Links
    NCBI Gene ID: 9568
    neXtProt AC: NX_O75899
    UniProt: O75899

  • Chr Location
    9q22.33; chr9:98288109-98708935 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human GABBR2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in clonic seizures, hyperactivity, hyperalgesia in response to thermal or mechanical stimuli, increased anxiety, and decreased depression-related behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    18
  • cDNA Data
    26
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242425 NCBI Gene Model | MGI Sequence Detail 329397 C57BL/6J ±  kb
    transcript NM_001081141 RefSeq | MGI Sequence Detail 5578 C57BL/6  
    polypeptide Q80T41 UniProt | EBI | MGI Sequence Detail 940 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007762 gamma-aminobutyric acid type B receptor subunit 2
      (term hierarchy)
    • InterPro Domains
      IPR041689 Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR002455 GPCR family 3, GABA-B receptor
      IPR002457 GPCR family 3, gamma-aminobutyric acid receptor, type B2
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q80T41 6 sites, 7 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 26
      Primer pair 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685271
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:326498 Ng GY, et al., Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity. J Biol Chem. 1999 Mar 19;274(12):7607-10
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory