Card14 MGI Mouse Gene Detail - MGI:2386258 - caspase recruitment domain family, member 14

Symbol

Card14
Name

caspase recruitment domain family, member 14
Synonyms

Bimp2, CARMA2

Feature Type

protein coding gene
IDs

MGI:2386258
NCBI Gene: 170720
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:119198594-119236201 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 83.36 cM
Mapping Data

1 experiment

SNPs within 2kb

1033 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2386258	protein coding gene	Chr11:119197923-119236205 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019479	protein coding gene	Chr11:123687501-123728489 (+)
A/J	MGP_AJ_G0019447	protein coding gene	Chr11:118210092-118245358 (+)
AKR/J	MGP_AKRJ_G0019417	protein coding gene	Chr11:121768332-121804085 (+)
BALB/cJ	MGP_BALBcJ_G0019422	protein coding gene	Chr11:118567991-118601696 (+)
C3H/HeJ	MGP_C3HHeJ_G0019228	protein coding gene	Chr11:122084075-122119163 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019871	protein coding gene	Chr11:127459958-127500353 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017496	protein coding gene	Chr11:115203137-115240369 (+)
CAST/EiJ	MGP_CASTEiJ_G0018782	protein coding gene	Chr11:123542407-123589251 (+)
CBA/J	MGP_CBAJ_G0019199	protein coding gene	Chr11:132415105-132454110 (+)
DBA/2J	MGP_DBA2J_G0019311	protein coding gene	Chr11:117582444-117615794 (+)
FVB/NJ	MGP_FVBNJ_G0019303	protein coding gene	Chr11:117249082-117287949 (+)
LP/J	MGP_LPJ_G0019383	protein coding gene	Chr11:123998008-124049880 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019336	protein coding gene	Chr11:131345485-131385893 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019910	protein coding gene	Chr11:122442180-122484908 (+)
PWK/PhJ	MGP_PWKPhJ_G0018548	protein coding gene	Chr11:118988158-119024598 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018340	protein coding gene	Chr11:122197654-122240607 (+)
WSB/EiJ	MGP_WSBEiJ_G0018834	protein coding gene	Chr11:122416469-122467249 (+)

Human Ortholog

CARD14, caspase recruitment domain family member 14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CARD14, caspase recruitment domain family member 14
Synonyms

BIMP2, CARMA2, PRP, PSORS2, PSS1
Links

HGNC:16446

NCBI Gene ID: 79092

neXtProt AC: NX_Q9BXL6

UniProt: Q9BXL6
Chr Location

17q25.3; chr17:80169992-80216073 (+) GRCh38

MGI Vertebrate Homology

Card14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CARD14
Gene Tree

Card14

Diseases

1 with Card14 mouse models; 2 with human CARD14 associations

Human Disease

Mouse Models

psoriasis 2

IDs

View 2 models

pityriasis rubra pilaris

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

21 phenotypes from 5 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

9
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show resistance to IMQ-induced psoriasiform disease. Heterozygotes for a gain-of-function allele develop chronic psoriasis with scaly lesions, epidermal thickening, keratinocyte hyperproliferation, hyperkeratosis and skin inflammation while homozygotes die within days of birth.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

6
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN card14

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All Sequences

59
RefSeq

26
UniProt

2
CCDS

CCDS25715.1

Ensembl

ENSMUSG00000013483 (Evidence)
NCBI Gene

170720

			Length	Strain/Species	Flank
genomic	ENSMUSG00000013483	Ensembl Gene Model \| MGI Sequence Detail	37608	C57BL/6J	± kb
transcript	ENSMUST00000106250	Ensembl \| MGI Sequence Detail	4206	Not Applicable
polypeptide	ENSMUSP00000101857	Ensembl \| MGI Sequence Detail	999	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005035 caspase recruitment domain-containing protein 14

(term hierarchy)
InterPro Domains

IPR001315 CARD domain

IPR011029 Death-like domain superfamily

IPR008144 Guanylate kinase-like domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 10

cDNA 10

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 1

Diseases 2

Gene Ontology 5

Phenotypes 14
Earliest

J:71748 McAllister-Lucas LM, et al., Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem. 2001 Aug 17;276(33):30589-97
Latest

J:353609 DeVore SB, et al., Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease. Cell Rep. 2024 Aug 27;43(8):114589

TSS for Card14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106176	Chr11:119198590-119198595 (+)	-1 bp
Tssr106177	Chr11:119205653-119205685 (+)	7,075 bp
Tssr106178	Chr11:119207804-119207835 (+)	9,226 bp
Tssr106179	Chr11:119207884-119207892 (+)	9,294 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24