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Csmd3 Gene Detail
Summary
  • Symbol
    Csmd3
  • Name
    CUB and Sushi multiple domains 3
  • Synonyms
    4930500N14Rik, mKIAA1894
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386403
    NCBI Gene: 239420
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:47444033-48655459 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 17.81 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38330 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386403
 protein coding gene Chr15:47444033-48655954 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021835
 protein coding gene Chr15:46293265-47626996 (-)
A/J MGP_AJ_G0021795
 protein coding gene Chr15:44519707-45736748 (-)
AKR/J MGP_AKRJ_G0021776
 protein coding gene Chr15:45775252-47028913 (-)
BALB/cJ MGP_BALBcJ_G0021802
 protein coding gene Chr15:44655932-45927043 (-)
C3H/HeJ MGP_C3HHeJ_G0021576
 protein coding gene Chr15:45779556-47085334 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022241
 protein coding gene Chr15:48133221-49467368 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019778
 protein coding gene Chr15:41786311-42983212 (-)
CAST/EiJ MGP_CASTEiJ_G0021093
 protein coding gene Chr15:46313192-47618713 (-)
CBA/J MGP_CBAJ_G0021545
 protein coding gene Chr15:49791275-51210553 (-)
DBA/2J MGP_DBA2J_G0021669
 protein coding gene Chr15:44338734-45595155 (-)
FVB/NJ MGP_FVBNJ_G0021647
 protein coding gene Chr15:43604167-44817853 (-)
LP/J MGP_LPJ_G0021739
 protein coding gene Chr15:46041467-47365043 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021671
 protein coding gene Chr15:53907809-55734403 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022264
 protein coding gene Chr15:46021514-47332878 (-)
PWK/PhJ MGP_PWKPhJ_G0020838
 protein coding gene Chr15:44424249-45677794 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020675
 protein coding gene Chr15:45739859-47121583 (-)
WSB/EiJ MGP_WSBEiJ_G0021148
 protein coding gene Chr15:45952318-47264518 (-)



Homology
more
  • Human Ortholog
    CSMD3, CUB and Sushi multiple domains 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSMD3, CUB and Sushi multiple domains 3
  • Links
    NCBI Gene ID: 114788
    neXtProt AC: NX_Q7Z407
    UniProt: Q7Z407

  • Chr Location
    8q23.3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disrupted allele exhibit growth retardation, defective object recognition memory and sociability, increased anxiety, and impaired neurogenesis in the cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    43
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022311 Ensembl Gene Model | MGI Sequence Detail 1211427 C57BL/6J ±  kb
    transcript ENSMUST00000162830 Ensembl | MGI Sequence Detail 13012 Not Applicable  
    polypeptide ENSMUSP00000124775 Ensembl | MGI Sequence Detail 3707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000032162 CUB and sushi domain-containing protein 3
      (term hierarchy)
    • InterPro Domains
      IPR000859 CUB domain
      IPR051277 SEZ6/CSMD/C4BPB Neuronal & Immune Regulators
      IPR035914 Spermadhesin, CUB domain superfamily
      IPR000436 Sushi/SCR/CCP domain
      IPR035976 Sushi/SCR/CCP superfamily
    • GlyGen
      Q80T79 27 sites, 13 N-linked glycans (12 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 3

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1922193
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 1
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory