About   Help   FAQ
Txnrd3 Gene Detail
Summary
  • Symbol
    Txnrd3
  • Name
    thioredoxin reductase 3
  • Synonyms
    Tgr, TR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386711
    NCBI Gene: 232223
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:89620970-89652511 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 40.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    792 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386711
 protein coding gene Chr6:89620970-89652511 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031021
 protein coding gene Chr6:91098454-91129976 (+)
A/J MGP_AJ_G0030987
 protein coding gene Chr6:87639019-87670583 (+)
AKR/J MGP_AKRJ_G0030918
 protein coding gene Chr6:90106805-90139501 (+)
BALB/cJ MGP_BALBcJ_G0031000
 protein coding gene Chr6:87609153-87640709 (+)
C3H/HeJ MGP_C3HHeJ_G0030710
 protein coding gene Chr6:94321053-94352568 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031457
 protein coding gene Chr6:93538129-93570737 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028638
 protein coding gene Chr6:85697870-85729414 (+)
CAST/EiJ MGP_CASTEiJ_G0030109
 protein coding gene Chr6:90215507-90249488 (+)
CBA/J MGP_CBAJ_G0030684
 protein coding gene Chr6:97044041-97077713 (+)
DBA/2J MGP_DBA2J_G0030840
 protein coding gene Chr6:86869659-86901208 (+)
FVB/NJ MGP_FVBNJ_G0030793
 protein coding gene Chr6:86072096-86103653 (+)
LP/J MGP_LPJ_G0030917
 protein coding gene Chr6:91130358-91163577 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030826
 protein coding gene Chr6:101174995-101207942 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031484
 protein coding gene Chr6:89947888-89979534 (+)
PWK/PhJ MGP_PWKPhJ_G0029824
 protein coding gene Chr6:85849387-85881013 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029652
 protein coding gene Chr6:88803292-88834293 (+)
WSB/EiJ MGP_WSBEiJ_G0030190
 protein coding gene Chr6:90403816-90435412 (+)



Homology
more
  • Human Ortholog
    TXNRD3, thioredoxin reductase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNRD3, thioredoxin reductase 3
  • Synonyms
    TGR, TR2, TR2IT1, TRXR3, TXNR3, TXNRD3IT1, TXNRD3NB, TXNRD3NT1
  • Links
    NCBI Gene ID: 114112
    neXtProt AC: NX_Q86VQ6
    UniProt: Q6F5E7, Q86VQ6

  • Chr Location
    3q21.3; chr3:126571779-126655124 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit reduced male fertility associated with oligozoospermia and asthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    102
  • cDNA Data
    33
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232223 NCBI Gene Model | MGI Sequence Detail 31542 C57BL/6J ±  kb
    transcript NM_153162 RefSeq | MGI Sequence Detail 2836 C57BL/6  
    polypeptide Q99MD6 UniProt | EBI | MGI Sequence Detail 652 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
      2LV3
    • EC
      1.8.1.9
    • InterPro Domains
      IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily
      IPR023753 FAD/NAD(P)-binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR002109 Glutaredoxin
      IPR011899 Glutaredoxin, eukaryotic/virial
      IPR046952 Glutathione reductase/thioredoxin reductase-like
      IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class I
      IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
      IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
      IPR006338 Thioredoxin/glutathione reductase selenoprotein
      IPR036249 Thioredoxin-like superfamily
    • GlyGen
      Q99MD6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 33
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1889389
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:57020 Sun QA, et al., Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J Biol Chem. 1999 Aug 27;274(35):24522-30
    • Latest
      J:330784 Dou Q, et al., Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis. J Biol Chem. 2022 Jun 23;298(8):102183
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory