Mboat1 MGI Mouse Gene Detail - MGI:2387184 - membrane bound O-acyltransferase domain containing 1

Symbol

Mboat1
Name

membrane bound O-acyltransferase domain containing 1
Synonyms

9130215M02Rik, MGC:38410, Oact1

Feature Type

protein coding gene
IDs

MGI:2387184
NCBI Gene: 218121
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr13:30320499-30430677 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.14 cM
Mapping Data

3 experiments

SNPs within 2kb

3381 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387184	protein coding gene	Chr13:30320472-30430700 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020412	protein coding gene	Chr13:27989458-28104153 (+)
A/J	MGP_AJ_G0020367	protein coding gene	Chr13:27281237-27391661 (+)
AKR/J	MGP_AKRJ_G0020344	protein coding gene	Chr13:27860295-27975433 (+)
BALB/cJ	MGP_BALBcJ_G0020362	protein coding gene	Chr13:27365373-27477624 (+)
C3H/HeJ	MGP_C3HHeJ_G0020165	protein coding gene	Chr13:27891500-28002211 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020798	protein coding gene	Chr13:28965828-29082185 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018389	protein coding gene	Chr13:25693999-25802491 (+)
CAST/EiJ	MGP_CASTEiJ_G0019682	protein coding gene	Chr13:27527311-27643406 (+)
CBA/J	MGP_CBAJ_G0020121	protein coding gene	Chr13:30212541-30337754 (+)
DBA/2J	MGP_DBA2J_G0020243	protein coding gene	Chr13:26826060-26932555 (+)
FVB/NJ	MGP_FVBNJ_G0020228	protein coding gene	Chr13:26426761-26536178 (+)
LP/J	MGP_LPJ_G0020320	protein coding gene	Chr13:28240124-28351170 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020254	protein coding gene	Chr13:30359154-30475929 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020839	protein coding gene	Chr13:27501107-27618777 (+)
PWK/PhJ	MGP_PWKPhJ_G0019437	protein coding gene	Chr13:26964934-27077932 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019258	protein coding gene	Chr13:26411735-26540476 (+)
WSB/EiJ	MGP_WSBEiJ_G0019744	protein coding gene	Chr13:27811281-27932273 (+)

Human Ortholog

MBOAT1, membrane bound O-acyltransferase domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MBOAT1, membrane bound O-acyltransferase domain containing 1
Synonyms

dJ434O11.1, LPEAT1, LPLAT, LPLAT 1, LPLAT14, LPSAT, OACT1
Links

HGNC:21579

NCBI Gene ID: 154141

neXtProt AC: NX_Q6ZNC8

UniProt: Q6ZNC8
Chr Location

6p22.3; chr6:20099684-20212469 (-) GRCh38

MGI Vertebrate Homology

Mboat1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MBOAT1
Gene Tree

Mboat1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Mboat1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

932
Tissues

146
cDNA Data

31
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mboat1

ZFIN mboat1

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All Sequences

48
RefSeq

11
UniProt

1
CCDS

CCDS26414.1

Ensembl

ENSMUSG00000038732 (Evidence)
NCBI Gene

218121

			Length	Strain/Species	Flank
genomic	218121	NCBI Gene Model \| MGI Sequence Detail	110179	C57BL/6J	± kb
transcript	NR_184863	RefSeq \| MGI Sequence Detail	2945	C57BL/6
polypeptide	Q8BH98	UniProt \| EBI \| MGI Sequence Detail	492	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010224 lysophospholipid acyltransferase 1

(term hierarchy)
EC

2.3.1.-, 2.3.1.23, 2.3.1.n6, 2.3.1.n7
InterPro Domains

IPR049941 Lysophospholipid acyltransferase 7/Porcupine-like

IPR004299 Membrane bound O-acyl transferase, MBOAT

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All nucleic 32

cDNA 31

Primer pair 1

Microarray probesets 2

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MGI:1924928

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 15
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mboat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4028	Chr13:30320446-30320474 (+)	-39 bp
Tssr119074	Chr13:30320489-30320510 (+)	1 bp
Tssr119075	Chr13:30320512-30320577 (+)	46 bp
Tssr119076	Chr13:30320584-30320593 (+)	90 bp
Tssr119077	Chr13:30320602-30320613 (+)	109 bp
Tssr119078	Chr13:30320620-30320633 (+)	128 bp
Tssr119079	Chr13:30329996-30329997 (+)	9,498 bp
Tssr119083	Chr13:30429603-30429608 (+)	109,107 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24