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Ift52 Gene Detail
Summary
  • Symbol
    Ift52
  • Name
    intraflagellar transport 52
  • Synonyms
    MGC:47065, NGD5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387217
    NCBI Gene: 245866
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:162859274-162888061 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 83.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    886 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387217
 protein coding gene Chr2:162859200-162888075 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026816
 protein coding gene Chr2:168305514-168339033 (+)
A/J MGP_AJ_G0026782
 protein coding gene Chr2:161553994-161584385 (+)
AKR/J MGP_AKRJ_G0026753
 protein coding gene Chr2:166318105-166347992 (+)
BALB/cJ MGP_BALBcJ_G0026791
 protein coding gene Chr2:161872751-161900995 (+)
C3H/HeJ MGP_C3HHeJ_G0026533
 protein coding gene Chr2:166669033-166699656 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027239
 protein coding gene Chr2:173254167-173283471 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024609
 protein coding gene Chr2:154845788-154874207 (+)
CAST/EiJ MGP_CASTEiJ_G0025994
 protein coding gene Chr2:167028309-167067903 (+)
CBA/J MGP_CBAJ_G0026510
 protein coding gene Chr2:179520919-179549787 (+)
DBA/2J MGP_DBA2J_G0026648
 protein coding gene Chr2:160722868-160753227 (+)
FVB/NJ MGP_FVBNJ_G0026614
 protein coding gene Chr2:159090390-159118483 (+)
LP/J MGP_LPJ_G0026751
 protein coding gene Chr2:168448790-168478691 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026636
 protein coding gene Chr2:183198133-183229231 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027295
 protein coding gene Chr2:166206306-166236584 (+)
PWK/PhJ MGP_PWKPhJ_G0025728
 protein coding gene Chr2:160269497-160299013 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025531
 protein coding gene Chr2:165066338-165096180 (+)
WSB/EiJ MGP_WSBEiJ_G0026064
 protein coding gene Chr2:167067518-167098055 (+)



Homology
more
  • Human Ortholog
    IFT52, intraflagellar transport 52
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFT52, intraflagellar transport 52
  • Synonyms
    C20orf9, CGI-53, NGD2, NGD5
  • Links
    NCBI Gene ID: 51098
    neXtProt AC: NX_Q9Y366
    UniProt: Q9Y366

  • Chr Location
    20q13.12; chr20:43590937-43647299 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IFT52 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality between E9 and E10.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017858 Ensembl Gene Model | MGI Sequence Detail 28788 C57BL/6J ±  kb
    transcript ENSMUST00000018002 Ensembl | MGI Sequence Detail 2248 Not Applicable  
    polypeptide ENSMUSP00000018002 Ensembl | MGI Sequence Detail 426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008935 intraflagellar transport protein 52
      (term hierarchy)
    • PDB
      5FMS
    • InterPro Domains
      IPR019196 ABC-type uncharacterised transport system
      IPR048643 Intraflagellar transport protein 52, C-terminal domain
      IPR039975 Intraflagellar transport protein 52 homolog
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    References
    more
    • Summaries
      All 48
      Gene Ontology 17
      Phenotypes 14
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory