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C1ql3 Gene Detail
Summary
  • Symbol
    C1ql3
  • Name
    C1q-like 3
  • Synonyms
    1110065A22Rik, K100
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387350
    NCBI Gene: 227580
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:13008268-13016617 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 9.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387350
 protein coding gene Chr2:13006591-13016617 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025353
 protein coding gene Chr2:10476287-10484624 (-)
A/J MGP_AJ_G0025330
 protein coding gene Chr2:10088513-10096826 (-)
AKR/J MGP_AKRJ_G0025299
 protein coding gene Chr2:10371516-10379849 (-)
BALB/cJ MGP_BALBcJ_G0025326
 protein coding gene Chr2:10069824-10078170 (-)
C3H/HeJ MGP_C3HHeJ_G0025086
 protein coding gene Chr2:10321926-10330259 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025768
 protein coding gene Chr2:10746129-10754601 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023183
 protein coding gene Chr2:9695098-9703375 (-)
CAST/EiJ MGP_CASTEiJ_G0024549
 protein coding gene Chr2:10291835-10300162 (-)
CBA/J MGP_CBAJ_G0025065
 protein coding gene Chr2:11218555-11226900 (-)
DBA/2J MGP_DBA2J_G0025197
 protein coding gene Chr2:9987149-9995486 (-)
FVB/NJ MGP_FVBNJ_G0025159
 protein coding gene Chr2:9884730-9893082 (-)
LP/J MGP_LPJ_G0025283
 protein coding gene Chr2:10375496-10383837 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025191
 protein coding gene Chr2:11105861-11114206 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025826
 protein coding gene Chr2:10293627-10301964 (-)
PWK/PhJ MGP_PWKPhJ_G0024300
 protein coding gene Chr2:9878136-9886498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024100
 protein coding gene Chr2:10330088-10338450 (-)
WSB/EiJ MGP_WSBEiJ_G0024619
 protein coding gene Chr2:10386940-10395239 (-)



Homology
more
  • Human Ortholog
    C1QL3, complement C1q like 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C1QL3, complement C1q like 3
  • Synonyms
    C1ql, C1QTNF13, CTRP13, K100
  • Links
    NCBI Gene ID: 389941
    neXtProt AC: NX_Q5VWW1
    UniProt: Q5VWW1

  • Chr Location
    10p13; chr10:16513734-16521879 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired coordination, hyperactivity, decreased anxiety-related response, impaired contextual conditioning behavior, impaired CPP, impaired conditioned taste aversion and reduced density of excitatory synapses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    64
  • cDNA Data
    7
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049630 Ensembl Gene Model | MGI Sequence Detail 8350 C57BL/6J ±  kb
    transcript ENSMUST00000061545 Ensembl | MGI Sequence Detail 2535 Not Applicable  
    polypeptide ENSMUSP00000056188 Ensembl | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 7
      Primer pair 4
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916171, MGI:2139035
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:78792 Koide T, et al., Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47. J Biol Chem. 2000 Sep 8;275(36):27957-63
    • Latest
      J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory