About   Help   FAQ
Pank4 Gene Detail
Summary
  • Symbol
    Pank4
  • Name
    pantothenate kinase 4
  • Synonyms
    D030031I12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387466
    NCBI Gene: 269614
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155048580-155065395 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 86.03 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387466
 protein coding gene Chr4:155048580-155065395 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029204
 protein coding gene Chr4:159251068-159267882 (+)
A/J MGP_AJ_G0029169
 protein coding gene Chr4:152567790-152584580 (+)
AKR/J MGP_AKRJ_G0029117
 protein coding gene Chr4:156727676-156744470 (+)
BALB/cJ MGP_BALBcJ_G0029185
 protein coding gene Chr4:153041681-153058465 (+)
C3H/HeJ MGP_C3HHeJ_G0028906
 protein coding gene Chr4:157261382-157278162 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029634
 protein coding gene Chr4:164945449-164962235 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026880
 protein coding gene Chr4:144868967-144885474 (+)
CAST/EiJ MGP_CASTEiJ_G0028319
 protein coding gene Chr4:154693031-154710264 (+)
CBA/J MGP_CBAJ_G0028868
 protein coding gene Chr4:169885179-169901951 (+)
DBA/2J MGP_DBA2J_G0029017
 protein coding gene Chr4:152592087-152608867 (+)
FVB/NJ MGP_FVBNJ_G0028981
 protein coding gene Chr4:151814246-151836040 (+)
LP/J MGP_LPJ_G0029107
 protein coding gene Chr4:159171798-159188581 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029008
 protein coding gene Chr4:172760619-172777409 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029666
 protein coding gene Chr4:157324215-157340995 (+)
PWK/PhJ MGP_PWKPhJ_G0028039
 protein coding gene Chr4:148713499-148730865 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027873
 protein coding gene Chr4:151600025-151616694 (+)
WSB/EiJ MGP_WSBEiJ_G0028399
 protein coding gene Chr4:157484419-157501129 (+)



Homology
more
  • Human Ortholog
    PANK4, pantothenate kinase 4 (inactive)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PANK4, pantothenate kinase 4 (inactive)
  • Synonyms
    CTRCT49
  • Links
    NCBI Gene ID: 55229
    neXtProt AC: NX_Q9NVE7
    UniProt: Q9NVE7

  • Chr Location
    1p36.32; chr1:2508537-2526597 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pank4 mouse models; 1 with human PANK4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop cataracts, with increased lens epithelial cell apoptosis, decreased lens epithelium thickness, and lens fiber abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    97
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269614 NCBI Gene Model | MGI Sequence Detail 16816 C57BL/6J ±  kb
    transcript NR_176005 RefSeq | MGI Sequence Detail 2766 ZRU/MplStud  
    polypeptide Q80YV4 UniProt | EBI | MGI Sequence Detail 820 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012258 4'-phosphopantetheine phosphatase
      (term hierarchy)
    • EC
      3.1.3.-
    • InterPro Domains
      IPR035073 At2g17340, three-helix bundle domain
      IPR043129 ATPase, nucleotide binding domain
      IPR002791 Damage-control phosphatase ARMT1-like, metal-binding domain
      IPR036075 Damage-control phosphatase ARMT1-like, metal-binding domain superfamily
      IPR015844 Pantothenate kinase, acetyl-CoA regulated, two-domain type
      IPR004567 Type II pantothenate kinase
    • GlyGen
      Q80YV4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2140718, MGI:2443534
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:336500 Shibata K, et al., Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine. J Nutr. 1983 Oct;113(10):2107-15
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory