Ahsa1 MGI Mouse Gene Detail - MGI:2387603 - AHA1, activator of heat shock protein ATPase 1

Symbol

Ahsa1
Name

AHA1, activator of heat shock protein ATPase 1
Synonyms

Aha1, MGC:36589, MGC:36618, p38

Feature Type

protein coding gene
IDs

MGI:2387603
NCBI Gene: 217737
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:87313253-87320772 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 41.47 cM
Mapping Data

1 experiment

SNPs within 2kb

234 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387603	protein coding gene	Chr12:87313189-87320772 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019984	protein coding gene	Chr12:88166390-88173641 (+)
A/J	MGP_AJ_G0019942	protein coding gene	Chr12:84817572-84824824 (+)
AKR/J	MGP_AKRJ_G0019917	protein coding gene	Chr12:87122305-87129556 (+)
BALB/cJ	MGP_BALBcJ_G0019921	protein coding gene	Chr12:85150758-85158009 (+)
C3H/HeJ	MGP_C3HHeJ_G0019727	protein coding gene	Chr12:87611440-87618691 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020373	protein coding gene	Chr12:90708843-90716094 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017991	protein coding gene	Chr12:81697522-81704777 (+)
CAST/EiJ	MGP_CASTEiJ_G0019277	protein coding gene	Chr12:82641964-82649203 (+)
CBA/J	MGP_CBAJ_G0019699	protein coding gene	Chr12:94180167-94187420 (+)
DBA/2J	MGP_DBA2J_G0019812	protein coding gene	Chr12:84313202-84320453 (+)
FVB/NJ	MGP_FVBNJ_G0019799	protein coding gene	Chr12:83307319-83314570 (+)
LP/J	MGP_LPJ_G0019886	protein coding gene	Chr12:88047370-88054621 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019838	protein coding gene	Chr12:96943067-96950324 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020405	protein coding gene	Chr12:86748767-86756018 (+)
PWK/PhJ	MGP_PWKPhJ_G0019041	protein coding gene	Chr12:78867451-78874728 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018836	protein coding gene	Chr12:81256455-81263684 (+)
WSB/EiJ	MGP_WSBEiJ_G0019330	protein coding gene	Chr12:87526473-87533723 (+)

Human Ortholog

AHSA1, activator of HSP90 ATPase activity 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AHSA1, activator of HSP90 ATPase activity 1
Synonyms

AHA1, C14orf3, hAha1, p38
Links

HGNC:1189

NCBI Gene ID: 10598

neXtProt AC: NX_O95433

UniProt: O95433
Chr Location

14q24.3; chr14:77457867-77469472 (+) GRCh38

MGI Vertebrate Homology

Ahsa1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AHSA1
Gene Tree

Ahsa1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

14
Targeted

3
Genomic Mutations

1 involving Ahsa1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

191

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ahsa1

ZFIN ahsa1a, ahsa1b

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All Sequences

49
RefSeq

4
UniProt

3
CCDS

CCDS26075.1

Ensembl

ENSMUSG00000021037 (Evidence)
NCBI Gene

217737

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021037	Ensembl Gene Model \| MGI Sequence Detail	7520	C57BL/6J	± kb
transcript	ENSMUST00000021425	Ensembl \| MGI Sequence Detail	1377	Not Applicable
polypeptide	ENSMUSP00000021425	Ensembl \| MGI Sequence Detail	338	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003860 activator of 90 kDa heat shock protein ATPase homolog 1

(term hierarchy)
InterPro Domains

IPR036338 Activator of Hsp90 ATPase, Aha1

IPR015310 Activator of Hsp90 ATPase AHSA1-like, N-terminal

IPR013538 Activator of Hsp90 ATPase homologue 1-like, C-terminal

IPR023393 START-like domain superfamily
GlyGen

Q8BK64 1 site, 1 O-linked glycan (1 site)

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All nucleic 191

cDNA 191

Microarray probesets 2

Summaries

All 37

Gene Ontology 7

Phenotypes 12
Earliest

J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ahsa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114520	Chr12:87311422-87311446 (+)	-1,819 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24