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Nek9 Gene Detail
Summary
  • Symbol
    Nek9
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 9
  • Synonyms
    C130021H08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387995
    NCBI Gene: 217718
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:85346288-85386136 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    874 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387995
 protein coding gene Chr12:85346288-85386136 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019959
 protein coding gene Chr12:86069655-86112161 (-)
A/J MGP_AJ_G0019916
 protein coding gene Chr12:82802487-82842911 (-)
AKR/J MGP_AKRJ_G0019892
 protein coding gene Chr12:85048585-85090740 (-)
BALB/cJ MGP_BALBcJ_G0019896
 protein coding gene Chr12:83146323-83186607 (-)
C3H/HeJ MGP_C3HHeJ_G0019702
 protein coding gene Chr12:85519319-85561656 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020347
 protein coding gene Chr12:88556190-88600819 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017965
 protein coding gene Chr12:79689433-79730577 (-)
CAST/EiJ MGP_CASTEiJ_G0019251
 protein coding gene Chr12:80490682-80532383 (-)
CBA/J MGP_CBAJ_G0019673
 protein coding gene Chr12:91931731-91976582 (-)
DBA/2J MGP_DBA2J_G0019788
 protein coding gene Chr12:82318906-82359689 (-)
FVB/NJ MGP_FVBNJ_G0019774
 protein coding gene Chr12:81281911-81323025 (-)
LP/J MGP_LPJ_G0019860
 protein coding gene Chr12:85945029-85985995 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019813
 protein coding gene Chr12:94810018-94852037 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020381
 protein coding gene Chr12:84651455-84695765 (-)
PWK/PhJ MGP_PWKPhJ_G0019015
 protein coding gene Chr12:76821309-76862761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018810
 protein coding gene Chr12:79130211-79175246 (-)
WSB/EiJ MGP_WSBEiJ_G0019303
 protein coding gene Chr12:85377852-85423499 (-)



Homology
more
  • Human Ortholog
    NEK9, NIMA related kinase 9
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEK9, NIMA related kinase 9
  • Synonyms
    APUG, LCCS10, NC, NERCC, NERCC1
  • Links
    NCBI Gene ID: 91754
    neXtProt AC: NX_Q8TD19
    UniProt: Q8TD19

  • Chr Location
    14q24.3; chr14:75079353-75127344 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NEK9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a small/hypocellular and hemorrhagic placenta with defects in placental labyrinth vasculature and trophoblast layer formation and complete lethality throughout fetal growth and development. A p.W972A mutation affects autophagy, leading to impaired renal tubule ciliogenesis, and tubule hypertrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    131
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217718 NCBI Gene Model | MGI Sequence Detail 39849 C57BL/6J ±  kb
    transcript NM_145138 RefSeq | MGI Sequence Detail 5403 C57BL/6  
    polypeptide Q8K1R7 UniProt | EBI | MGI Sequence Detail 984 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011135 serine/threonine-protein kinase Nek9
      (term hierarchy)
    • PDB
      5DE2
    • EC
      2.7.11.1
    • InterPro Domains
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR000408 Regulator of chromosome condensation, RCC1
      IPR008271 Serine/threonine-protein kinase, active site
      IPR051997 Serine/threonine-protein kinase NEK
      IPR042767 Serine/threonine-protein kinase Nek9, catalytic domain
    • GlyGen
      Q8K1R7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 132
      cDNA 131
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442375
    References
    more
    • Summaries
      All 43
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory