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Liph Gene Detail
Summary
  • Symbol
    Liph
  • Name
    lipase, member H
  • Synonyms
    C130037N08Rik, D16Wsu119e, Lpdlr, LPDLR, mPA-PLA1, PLA1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388029
    NCBI Gene: 239759
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21772567-21814408 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.95 cM, cytoband B1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1278 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388029
 protein coding gene Chr16:21772567-21814413 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022664
 protein coding gene Chr16:19410083-19458794 (-)
A/J MGP_AJ_G0022626
 protein coding gene Chr16:18474834-18519188 (-)
AKR/J MGP_AKRJ_G0022601
 protein coding gene Chr16:19244035-19291087 (-)
BALB/cJ MGP_BALBcJ_G0022630
 protein coding gene Chr16:18670857-18717949 (-)
C3H/HeJ MGP_C3HHeJ_G0022395
 protein coding gene Chr16:19346696-19400289 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023081
 protein coding gene Chr16:19811854-19877393 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020599
 protein coding gene Chr16:19174952-19221633 (-)
CAST/EiJ MGP_CASTEiJ_G0021925
 protein coding gene Chr16:19332166-19382966 (-)
CBA/J MGP_CBAJ_G0022367
 protein coding gene Chr16:20633998-20704574 (-)
DBA/2J MGP_DBA2J_G0022499
 protein coding gene Chr16:18457209-18502312 (-)
FVB/NJ MGP_FVBNJ_G0022474
 protein coding gene Chr16:18432967-18473602 (-)
LP/J MGP_LPJ_G0022566
 protein coding gene Chr16:19157684-19206062 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022494
 protein coding gene Chr16:20236317-20288263 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023092
 protein coding gene Chr16:19194401-19241880 (-)
PWK/PhJ MGP_PWKPhJ_G0021665
 protein coding gene Chr16:18691182-18733657 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021495
 protein coding gene Chr16:18971656-19019647 (-)
WSB/EiJ MGP_WSBEiJ_G0021968
 protein coding gene Chr16:19157388-19200280 (-)



Homology
more
  • Human Ortholog
    LIPH, lipase H
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIPH, lipase H
  • Synonyms
    AH, ARWH2, HYPT7, LAH2, LPDLR, mPA-PLA1, PLA1B
  • Links
    NCBI Gene ID: 200879
    neXtProt AC: NX_Q8WWY8
    UniProt: Q8WWY8

  • Chr Location
    3q27.2; chr3:185506262-185552588 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LIPH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit wavy vibrissae and wavy and matted coats associated with impaired inner rooth sheath formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    30
  • cDNA Data
    40
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239759 NCBI Gene Model | MGI Sequence Detail 41842 C57BL/6J ±  kb
    transcript NM_001289581 RefSeq | MGI Sequence Detail 3870 ZRU/MplStud  
    polypeptide Q8CIV3 UniProt | EBI | MGI Sequence Detail 451 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 6
      cDNA 40
      Primer pair 3
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35700, MGI:107235, MGI:1206038, MGI:1206041, MGI:2444423
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:37738 Kalcheva I, et al., The gene encoding beta-galactoside alpha2,6-sialyltransferase maps to mouse chromosome 16. Mamm Genome. 1997 Aug;8(8):619-20
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory