Tg(CD2-Il5)5C2Ldt
Transgene Detail

Summary

• Symbol: Tg(CD2-Il5)5C2Ldt
• Name: transgene insertion 5C2, Lindsay A Dent
• MGI ID: MGI:2182291
• Synonyms: Tg5C2
• Transgene: Tg(CD2-Il5)5C2Ldt Location: unknown
• Alliance: Tg(CD2-Il5)5C2Ldt page

Transgene origin

• Strain of Origin: CBA/Ca

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Il5)5C2Ldt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il5 (MGI:96557)

• Mutation details: 10 kb of genomic mouse Il5 sequences under the control of the dominant control region (DCR) from human CD2 was used for the transgene. The DCR drives thymocyte and T cell specific expression. (J:76902)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Northern blot analysis confirmed transgene expression in the thymus, Peyer's patches and subcutaneous lymph nodes of transgenic animals. Founders Tg5C1 and Tg5C2 carry 8 and 49 copies of the transgene, respectively, and express 65X and 265X the amount of blood eosinophils of nontransgenic littermates, respectively.

References

• Original: J:76902 Dent LA, et al., Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med. 1990 Nov 1;172(5):1425-31
• All: 14 reference(s)