Tg(PMP22)C22Clh
Transgene Detail

Summary

• Symbol: Tg(PMP22)C22Clh
• Name: transgene insertion C22, Clare Huxley
• MGI ID: MGI:2183770
• Synonyms: C22
• Transgene: Tg(PMP22)C22Clh Location: unknown Genetic Position: Chr8, Syntenic
• Alliance: Tg(PMP22)C22Clh page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PMP22)C22Clh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PMP22 (5376)

  Pmp22

  (MGI:97631)

• Mutation details: A YAC containing the human PMP22 gene with 300 kb of upstream and 100 kb of downstream sequences was used as the transgene. STS analysis using 6 markers spanning the YAC showed the integrated transgene was largely intact including the region containing PMP22. Founder C22 carries 8 copies of the human transgene on chromosome 8 with an expression pattern similar to that of the endogenous mouse gene. The expression level of each human transgene is approximately 0.4X that of one mouse gene. (J:78221)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:78221 Huxley C, et al., Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA. Hum Mol Genet. 1996 May;5(5):563-9
• All: 17 reference(s)