Tg(Rbp3-SV40)IT-2Jjw
Transgene Detail

Summary

• Symbol: Tg(Rbp3-SV40)IT-2Jjw
• Name: transgene insertion IT-2, Jolene J Windle
• MGI ID: MGI:2385652
• Synonyms: IRBP-Tag
• Transgene: Tg(Rbp3-SV40)IT-2Jjw Location: unknown
• Alliance: Tg(Rbp3-SV40)IT-2Jjw page

Transgene origin

• Strain of Origin: (BALB/cAnNHsd x C57BL/6NHsd)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: 2.7 kb of the SV40 T antigen gene fused to 1.9 kb of mouse RBP3 promoter sequences was used as the transgene. Promoter sequences from -1783 to +101 were used to drive expression of the transgene in photoreceptor cells. Northern blot analysis confirmed transgene expression in the retina and pineal of transgenic animals. (J:60231)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Rbp3-SV40)IT-2Jjw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic animals develop retinal and pineal tumors by 10-12 weeks of age with 100% penetrance. Transgenic animals carrying the greatest transgene copy number (15-50) also displayed a 25%-30% decrease in body weight compared to non-transgenic animals.

References

• Original: J:60231 Howes KA, et al., Photoreceptor cell tumors in transgenic mice. Invest Ophthalmol Vis Sci. 1994 Feb;35(2):342-51
• All: 3 reference(s)