Tg(RHO-P23H)DTpd
Transgene Detail

Summary

• Symbol: Tg(RHO-P23H)DTpd
• Name: transgene insertion D, Thaddeus P Dryja
• MGI ID: MGI:2181671
• Synonyms: P23H-D
• Transgene: Tg(RHO-P23H)DTpd Location: unknown
• Alliance: Tg(RHO-P23H)DTpd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(RHO-P23H)DTpd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RHO (6010)

  Rho	(MGI:97914)

• Mutation details: The entire coding region of mutant human rhodopsin (P23H) implicated in dominantly inherited retinitis pigmentosa was used for the transgene. The transgene includes 4.2 kb of upstream sequence and 8.4 kb of downstream sequence. (J:76722)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Mutant lines D, E, and L harboring the mutant human rhodopsin gene were constructed. Lines D and E express 3x and 1x the amount of endogenous rhodopsin, respectively, resulting in severe retinitis pigmentosa. Line L expresses 1/6x the amount of endogenous rhodopsin and exhibits a mild disease phenotype.

References

• Original: J:76722 Olsson JE, et al., Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron. 1992 Nov;9(5):815-30
• All: 4 reference(s)