Retreg2 MGI Mouse Gene Detail - MGI:2388278 - reticulophagy regulator family member 2

Symbol

Retreg2
Name

reticulophagy regulator family member 2
Synonyms

Fam134a, MGC47289

Feature Type

protein coding gene
IDs

MGI:2388278
NCBI Gene: 227298
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:75119432-75124553 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.61 cM
Mapping Data

1 experiment

SNPs within 2kb

144 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388278	protein coding gene	Chr1:75119422-75124557 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016172	protein coding gene	Chr1:75703690-75708867 (+)
A/J	MGP_AJ_G0016155	protein coding gene	Chr1:73063564-73068684 (+)
AKR/J	MGP_AKRJ_G0016112	protein coding gene	Chr1:75092052-75097180 (+)
BALB/cJ	MGP_BALBcJ_G0016110	protein coding gene	Chr1:73126798-73131933 (+)
C3H/HeJ	MGP_C3HHeJ_G0015941	protein coding gene	Chr1:75423380-75428513 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016563	protein coding gene	Chr1:78655571-78660701 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014284	protein coding gene	Chr1:68626534-68631668 (+)
CAST/EiJ	MGP_CASTEiJ_G0015525	protein coding gene	Chr1:74760185-74765261 (+)
CBA/J	MGP_CBAJ_G0015914	protein coding gene	Chr1:81209109-81214240 (+)
DBA/2J	MGP_DBA2J_G0016015	protein coding gene	Chr1:72383451-72388574 (+)
FVB/NJ	MGP_FVBNJ_G0016018	protein coding gene	Chr1:71579882-71585851 (+)
LP/J	MGP_LPJ_G0016087	protein coding gene	Chr1:76827524-76832660 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016038	protein coding gene	Chr1:84570228-84575369 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016610	protein coding gene	Chr1:75160448-75165584 (+)
PWK/PhJ	MGP_PWKPhJ_G0015312	protein coding gene	Chr1:71851699-71856851 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015090	protein coding gene	Chr1:74522714-74527822 (+)
WSB/EiJ	MGP_WSBEiJ_G0015587	protein coding gene	Chr1:74973854-74978987 (+)

Human Ortholog

RETREG2, reticulophagy regulator family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RETREG2, reticulophagy regulator family member 2
Synonyms

C2orf17, FAM134A, MAG-2
Links

HGNC:28450

NCBI Gene ID: 79137

neXtProt AC: NX_Q8NC44

UniProt: Q8NC44
Chr Location

2q35; chr2:219176225-219185475 (+) GRCh38

MGI Vertebrate Homology

Retreg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RETREG2
Gene Tree

Retreg2

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Spontaneous

1
Targeted

1
Genomic Mutations

4 involving Retreg2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

48
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase retreg2

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All Sequences

104
RefSeq

36
UniProt

6
CCDS

CCDS35621.1, CCDS78621.1

Ensembl

ENSMUSG00000049339 (Evidence)
NCBI Gene

227298

			Length	Strain/Species	Flank
genomic	227298	NCBI Gene Model \| MGI Sequence Detail	5122	C57BL/6J	± kb
transcript	NM_170755	RefSeq \| MGI Sequence Detail	2555	C57BL/6
polypeptide	Q6NS82	UniProt \| EBI \| MGI Sequence Detail	541	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000031519 reticulophagy regulator 2

(term hierarchy)
InterPro Domains

IPR052114 ER-associated autophagy and membrane dynamics regulator

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All nucleic 12

cDNA 12

Microarray probesets 3

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MGI:5897460

Summaries

All 47

Developmental Gene Expression 3

Diseases 1

Gene Ontology 3

Phenotypes 23
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:354136 Iavarone F, et al., Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo. EMBO Rep. 2024 Jul 22;

TSS for Retreg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7486	Chr1:75119077-75119127 (+)	-330 bp
Tssr7487	Chr1:75119146-75119163 (+)	-277 bp
Tssr7488	Chr1:75119362-75119386 (+)	-58 bp
Tssr7489	Chr1:75119406-75119417 (+)	-20 bp
Tssr7490	Chr1:75119419-75119441 (+)	-2 bp
Tssr7491	Chr1:75119457-75119468 (+)	31 bp
Tssr7492	Chr1:75119472-75119481 (+)	45 bp
Tssr7493	Chr1:75119887-75119915 (+)	469 bp
Tssr7494	Chr1:75123942-75123962 (+)	4,520 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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