Tg(Pmp22)247Ueli
Transgene Detail

Summary

• Symbol: Tg(Pmp22)247Ueli
• Name: transgene insertion 247, Ueli Suter
• MGI ID: MGI:2183755
• Synonyms: TgN247, TgN(pmp22Ge)247Zbz
• Transgene: Tg(Pmp22)247Ueli Location: unknown
• Alliance: Tg(Pmp22)247Ueli page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pmp22)247Ueli expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pmp22 (MGI:97631)

• Mutation details: The entire mouse Pmp22 gene including 7 kb of upstream and 4 kb of downstream sequences was used as the transgene. (J:34938)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founder 247 is representative of 2 founders (247 and 249) carrying approximately 30 copies of the transgene and exhibiting similar phenotypes. Transgenic animals display slight shivering at 2 weeks of age most apparent in the head. At 4 weeks the animals exhibit unsteady gait and progress to muscle atrophy at 2-3 months leading eventually to hind limb paralysis.

References

• Original: J:34938 Magyar JP, et al., Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage. J Neurosci. 1996 Sep 1;16(17):5351-60
• All: 4 reference(s)