Tg(SOD1*G93A)1Gur
Transgene Detail

Summary

• Symbol: Tg(SOD1*G93A)1Gur
• Name: transgene insertion 1, Mark E Gurney
• MGI ID: MGI:2183719
• Synonyms: G1H, G93A, G93A+, G93A SOD1, G93A-SOD1, (G93A)Tg+, Gur1-G93A, hSOD1G93A, SOD1 G93A, SOD1^G93A, SOD1 Tg, Tg(G93A-SOD1)1Gur, TgN(SOD1-G93A)1Gur, TgN[SOD1-G93A]1Gur, Tg(SOD1-G93A)1Gur
• Transgene: Tg(SOD1*G93A)1Gur Location: Chr12:97132574-97132574 bp Genetic Position: Chr12, cytoband E
• Alliance: Tg(SOD1*G93A)1Gur page

Presence of neurofilament spheroids in the spinal cord of an 82-day old Tg(SOD1)2Gur/0 mouse

Show the 5 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*G93A)1Gur expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: This transgenic subline (designated G1H in J:76718) is derived from the G1 parental transgenic line (originally described in J:32665). This line carries a 40% expansion in transgene copy number compared to the original G1 line (described in J:32665, in MGI as Tg(SOD1*G93A)2Gur). The transgene construct is composed of the human SOD1 gene carrying a glycine to alanine transition at position 93 (G93A). The G93A mutation does not alter the activity of the protein. This line carries a high copy number maps to Mus Chr12:97,165,800 (coordinates from MGSC ver 37, mm9). (J:32665, J:76718)

Disease models

Expression

In Structures Affected by this Mutation:

29 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

Notes

This line, G1H, was derived from the original G1 line (now designated Tg(SOD1*G93A)2Gur) reported in J:32665.

Transgenic mice on a background that involves C57BL/6 and SJL express high levels of the transgene with a 4-fold increase in SOD activity, and exhibit a phenotype similar to amyotrophic lateral sclerosis (ALS) in humans. Hemizygous transgenic mice become paralyzed in one or more limbs and have a life span of approximately 19-23 weeks. Paralysis is due to loss of motor neurons from the spinal cord.

References

• Original: J:76718 Tu PH, et al., Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3155-60
• All: 1127 reference(s)