Igsf11 MGI Mouse Gene Detail - MGI:2388477 - immunoglobulin superfamily, member 11

Symbol

Igsf11
Name

immunoglobulin superfamily, member 11
Synonyms

1700025L02Rik, BT-IgSF

Feature Type

protein coding gene
IDs

MGI:2388477
NCBI Gene: 207683
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr16:38713033-38847521 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 26.87 cM
Mapping Data

2 experiments

SNPs within 2kb

4153 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388477	protein coding gene	Chr16:38712840-38847521 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022824	protein coding gene	Chr16:37448163-37583624 (+)
A/J	MGP_AJ_G0022789	protein coding gene	Chr16:35586696-35722158 (+)
AKR/J	MGP_AKRJ_G0022761	protein coding gene	Chr16:36935403-37069277 (+)
BALB/cJ	MGP_BALBcJ_G0022790	protein coding gene	Chr16:35699994-35834596 (+)
C3H/HeJ	MGP_C3HHeJ_G0022554	protein coding gene	Chr16:37029880-37178599 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023237	protein coding gene	Chr16:38309522-38442888 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020752	protein coding gene	Chr16:35954602-36083760 (+)
CAST/EiJ	MGP_CASTEiJ_G0022080	protein coding gene	Chr16:37202021-37339305 (+)
CBA/J	MGP_CBAJ_G0022525	protein coding gene	Chr16:39979916-40132055 (+)
DBA/2J	MGP_DBA2J_G0022657	protein coding gene	Chr16:35461060-35596162 (+)
FVB/NJ	MGP_FVBNJ_G0022632	protein coding gene	Chr16:35486495-35617449 (+)
LP/J	MGP_LPJ_G0022725	protein coding gene	Chr16:37108412-37243935 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022651	protein coding gene	Chr16:39066443-39216843 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023252	protein coding gene	Chr16:36904349-37039667 (+)
PWK/PhJ	MGP_PWKPhJ_G0021820	protein coding gene	Chr16:35887576-36014234 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021651	protein coding gene	Chr16:36789147-36915845 (+)
WSB/EiJ	MGP_WSBEiJ_G0022124	protein coding gene	Chr16:36964361-37101265 (+)

Human Ortholog

IGSF11, immunoglobulin superfamily member 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGSF11, immunoglobulin superfamily member 11
Synonyms

BT-IgSF, BTIGSF, CT119, CXADRL1, Igsf13, VSIG3
Links

HGNC:16669

NCBI Gene ID: 152404

neXtProt AC: NX_Q5DX21

UniProt: Q5DX21
Chr Location

3q13.32; chr3:118900557-119146068 (-) GRCh38

MGI Vertebrate Homology

Igsf11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IGSF11
Gene Tree

Igsf11

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Targeted

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit disrupted synaptic transmission and plasticity.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

27
cDNA Data

18
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

6
UniProt

2
CCDS

CCDS28175.1

Ensembl

ENSMUSG00000022790 (Evidence)
NCBI Gene

207683

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022790	Ensembl Gene Model \| MGI Sequence Detail	134489	C57BL/6J	± kb
transcript	ENSMUST00000023478	Ensembl \| MGI Sequence Detail	3443	Not Applicable
polypeptide	ENSMUSP00000023478	Ensembl \| MGI Sequence Detail	428	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008970 immunoglobulin superfamily member 11

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR042758 Immunoglobulin superfamily member 11

IPR013106 Immunoglobulin V-set domain
GlyGen

P0C673 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 19

cDNA 18

Other 1

Microarray probesets 1

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MGI:1919108

Summaries

All 44

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:346440 Pelz L, et al., The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte coupling in mice. eNeuro. 2024 Feb 22;11(3):ENEURO.0283-23.2024

TSS for Igsf11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138417	Chr16:38712864-38712896 (+)	-153 bp
Tssr138418	Chr16:38721602-38721651 (+)	8,594 bp
Tssr138419	Chr16:38722615-38722659 (+)	9,604 bp
Tssr138420	Chr16:38722667-38722678 (+)	9,640 bp
Tssr138421	Chr16:38722687-38722726 (+)	9,674 bp
Tssr138422	Chr16:38722734-38722799 (+)	9,734 bp
Tssr138423	Chr16:38722800-38722824 (+)	9,779 bp
Tssr138424	Chr16:38730472-38730477 (+)	17,442 bp
Tssr138425	Chr16:38752252-38752257 (+)	39,222 bp
Tssr138426	Chr16:38846151-38846166 (+)	133,126 bp
Tssr138427	Chr16:38846550-38846557 (+)	133,521 bp
Tssr138428	Chr16:38847105-38847109 (+)	134,074 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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