Abca13 MGI Mouse Gene Detail - MGI:2388707 - ATP-binding cassette, sub-family A member 13

Symbol

Abca13
Name

ATP-binding cassette, sub-family A member 13
Synonyms

A930002G16Rik

Feature Type

protein coding gene
IDs

MGI:2388707
NCBI Gene: 268379
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:9141942-9634259 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 6.13 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

14749 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388707	protein coding gene	Chr11:9141942-9634871 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018041	protein coding gene	Chr11:6440301-6945890 (+)
A/J	MGP_AJ_G0018014	protein coding gene	Chr11:6163597-6662681 (+)
AKR/J	MGP_AKRJ_G0017978	protein coding gene	Chr11:6385880-6909795 (+)
BALB/cJ	MGP_BALBcJ_G0017982	protein coding gene	Chr11:6155399-6676588 (+)
C3H/HeJ	MGP_C3HHeJ_G0017795	protein coding gene	Chr11:6304054-6827231 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018434	protein coding gene	Chr11:6596844-7152522 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016092	protein coding gene	Chr11:5885175-6356785 (+)
CAST/EiJ	MGP_CASTEiJ_G0017357	protein coding gene	Chr11:6327799-6843568 (+)
CBA/J	MGP_CBAJ_G0017770	protein coding gene	Chr11:7160524-7721087 (+)
DBA/2J	MGP_DBA2J_G0017880	protein coding gene	Chr11:6121223-6611653 (+)
FVB/NJ	MGP_FVBNJ_G0017872	protein coding gene	Chr11:6070740-6554450 (+)
LP/J	MGP_LPJ_G0017951	protein coding gene	Chr11:6476931-6986094 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017898	protein coding gene	Chr11:6707813-7277849 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018474	protein coding gene	Chr11:6530928-7026635 (+)
PWK/PhJ	MGP_PWKPhJ_G0017137	protein coding gene	Chr11:6098455-6618916 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016934	protein coding gene	Chr11:6352414-6817293 (+)
WSB/EiJ	MGP_WSBEiJ_G0017411	protein coding gene	Chr11:6269703-6784829 (+)

Human Ortholog

ABCA13, ATP binding cassette subfamily A member 13

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABCA13, ATP binding cassette subfamily A member 13
Links

HGNC:14638

NCBI Gene ID: 154664

neXtProt AC: NX_Q86UQ4

UniProt: Q86UQ4
Chr Location

7p12.3; chr7:48171458-48647497 (+) GRCh38

MGI Vertebrate Homology

Abca13 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ABCA13
Gene Tree

Abca13

Diseases

1 with human ABCA13 associations

				Human Disease	Mouse Models
				gastric adenocarcinoma IDs gastric adenocarcinoma DOID:3717 NCI:C4004 UMLS_CUI:C0278701

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

297 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced prepulse inhibition and vesicular cholesterol accumulation and synaptic vesicle endocytosis are impaired in primary cortical neurons.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

825
Tissues

111
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS36110.1

Ensembl

ENSMUSG00000004668 (Evidence)
NCBI Gene

268379

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004668	Ensembl Gene Model \| MGI Sequence Detail	492318	C57BL/6J	± kb
transcript	ENSMUST00000042740	Ensembl \| MGI Sequence Detail	16011	Not Applicable
polypeptide	ENSMUSP00000040465	Ensembl \| MGI Sequence Detail	5034	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031308 ATP-binding cassette sub-family A member 13

(term hierarchy)
EC

7.6.2.-
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR013525 ABC-2 type transporter, transmembrane domain

IPR026082 ABC transporter A

IPR003439 ABC transporter-like, ATP-binding domain

IPR017871 ABC transporter-like, conserved site

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q5SSE9 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 17

cDNA 13

Primer pair 4

Microarray probesets 3

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MGI:2144330

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Abca13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100335	Chr11:9141769-9141779 (+)	-168 bp
Tssr100336	Chr11:9141790-9141799 (+)	-147 bp
Tssr100337	Chr11:9141934-9141948 (+)	-1 bp
Tssr100338	Chr11:9143415-9143428 (+)	1,480 bp
Tssr100339	Chr11:9205627-9205628 (+)	63,686 bp
Tssr3425	Chr11:9548077-9548078 (+)	406,136 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24