Tg(Ins1-GAS)1Sbr
Transgene Detail

Summary

• Symbol: Tg(Ins1-GAS)1Sbr
• Name: transgene insertion 1, Stephen J Brand
• MGI ID: MGI:2388566
• Synonyms: INS-GAS, INSGAS
• Transgene: Tg(Ins1-GAS)1Sbr Location: unknown
• Alliance: Tg(Ins1-GAS)1Sbr page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins1-GAS)1Sbr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GAST (2520)

  Gast	(MGI:104768)

• Mutation details: 1.5 kb of human GAS sequences encoding the preprogastrin peptide precursor (intron 1, exon 2, and exon 3) was used for the transgene. Nucleotides -370 to +38 of the rat insulin 1 gene (Ins1) drive transgene expression in beta islet cells. (J:78615)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ins1-GAS)1Sbr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:78615 Wang TC, et al., Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest. 1993 Sep;92(3):1349-56
• All: 28 reference(s)