Tg(Myh6-CASQ2)1Mord
Transgene Detail

Summary

• Symbol: Tg(Myh6-CASQ2)1Mord
• Name: transgene insertion 1, Martin Morad
• MGI ID: MGI:2389055
• Synonyms: CSQ, MHC-CSQ, Tg(Myhca-Casq2)1Mord
• Transgene: Tg(Myh6-CASQ2)1Mord Location: unknown
• Alliance: Tg(Myh6-CASQ2)1Mord page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-CASQ2)1Mord expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  dog	CASQ2 (483134)

• Mutation details: The transgene is composed of full length canine cardiac calsequestrin cDNA and 135 bp of 5'- and 10 bp of 3'-untranslated sequences fused to the mouse Myhca promoter and an SV40 polyadenylation sequence. The Myhca promoter directs expression of the transgene in the heart. Western blot analysis showed that transgene expression is 10-fold greater compared to endogenous levels. (J:46786)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:46786 Jones LR, et al., Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin. J Clin Invest. 1998 Apr 1;101(7):1385-93
• All: 22 reference(s)