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Lrrtm1 Gene Detail
Summary
  • Symbol
    Lrrtm1
  • Name
    leucine rich repeat transmembrane neuronal 1
  • Synonyms
    4632401D06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389173
    NCBI Gene: 74342
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:77219672-77234774 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 33.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389173
 protein coding gene Chr6:77192762-77236898 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030891
 protein coding gene Chr6:78031276-78046212 (+)
A/J MGP_AJ_G0030860
 protein coding gene Chr6:74964020-74979071 (+)
AKR/J MGP_AKRJ_G0030789
 protein coding gene Chr6:77215445-77230672 (+)
BALB/cJ MGP_BALBcJ_G0030871
 protein coding gene Chr6:75053133-75069587 (+)
C3H/HeJ MGP_C3HHeJ_G0030842
 protein coding gene Chr6:107055780-107070750 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031329
 protein coding gene Chr6:80098911-80113768 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028518
 protein coding gene Chr6:73830881-73846101 (+)
CAST/EiJ MGP_CASTEiJ_G0029979
 protein coding gene Chr6:77138108-77153022 (+)
CBA/J MGP_CBAJ_G0030558
 protein coding gene Chr6:83295250-83310213 (+)
DBA/2J MGP_DBA2J_G0030710
 protein coding gene Chr6:74361608-74376544 (+)
FVB/NJ MGP_FVBNJ_G0030663
 protein coding gene Chr6:73635088-73651037 (+)
LP/J MGP_LPJ_G0030790
 protein coding gene Chr6:77944901-77959744 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030698
 protein coding gene Chr6:87280727-87297526 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031355
 protein coding gene Chr6:77066032-77080944 (+)
PWK/PhJ MGP_PWKPhJ_G0029695
 protein coding gene Chr6:73318085-73333158 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029523
 protein coding gene Chr6:75838840-75853640 (+)
WSB/EiJ MGP_WSBEiJ_G0030061
 protein coding gene Chr6:77428107-77444989 (+)



Homology
more
  • Human Ortholog
    LRRTM1, leucine rich repeat transmembrane neuronal 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRTM1, leucine rich repeat transmembrane neuronal 1
  • Links
    NCBI Gene ID: 347730
    neXtProt AC: NX_Q86UE6
    UniProt: Q86UE6

  • Chr Location
    2p12; chr2:80288351-80304752 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lrrtm1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired cognitive function and altered hippocampal synapse morphology. When conditionally deleted in addition to Lrrtm2, mice homozygous for a conditional allele exhibit impaired basal AMPA receptor transmission and LTP.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1012
  • Tissues
    108
  • cDNA Data
    22
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060780 Ensembl Gene Model | MGI Sequence Detail 15103 C57BL/6J ±  kb
    transcript ENSMUST00000159616 Ensembl | MGI Sequence Detail 2541 Not Applicable  
    polypeptide ENSMUSP00000125207 Ensembl | MGI Sequence Detail 522 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000009946 leucine-rich repeat transmembrane neuronal protein 1
      (term hierarchy)
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR050328 Multifunctional Developmental and Immune Receptor
    • GlyGen
      Q8K377 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921592, MGI:2141653
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory