Txndc2 MGI Mouse Gene Detail - MGI:2389312 - thioredoxin domain containing 2 (spermatozoa)

Symbol

Txndc2
Name

thioredoxin domain containing 2 (spermatozoa)
Synonyms

Sptrx-1

Feature Type

protein coding gene
IDs

MGI:2389312
NCBI Gene: 213272
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr17:65944502-65949163 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 34.99 cM, cytoband E1.2-E1.3
Mapping Data

2 experiments

SNPs within 2kb

219 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2389312	protein coding gene	Chr17:65944498-65955871 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023978	protein coding gene	Chr17:67769207-67773821 (-)
A/J	MGP_AJ_G0023936	protein coding gene	Chr17:65750113-65754727 (-)
AKR/J	MGP_AKRJ_G0023905	protein coding gene	Chr17:66664729-66669343 (-)
BALB/cJ	MGP_BALBcJ_G0023937	protein coding gene	Chr17:65685231-65689845 (-)
C3H/HeJ	MGP_C3HHeJ_G0023701	protein coding gene	Chr17:67552892-67557506 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024383	protein coding gene	Chr17:70400690-70405304 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021829	protein coding gene	Chr17:61780098-61785157 (-)
CAST/EiJ	MGP_CASTEiJ_G0023183	protein coding gene	Chr17:67891085-67895665 (-)
CBA/J	MGP_CBAJ_G0023677	protein coding gene	Chr17:73149938-73154597 (-)
DBA/2J	MGP_DBA2J_G0023805	protein coding gene	Chr17:64494686-64499300 (-)
FVB/NJ	MGP_FVBNJ_G0023771	protein coding gene	Chr17:63983891-63988505 (-)
LP/J	MGP_LPJ_G0023887	protein coding gene	Chr17:68495033-68499647 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023799	protein coding gene	Chr17:73252482-73257096 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024427	protein coding gene	Chr17:67132178-67136793 (-)
PWK/PhJ	MGP_PWKPhJ_G0022929	protein coding gene	Chr17:63763499-63768102 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022740	protein coding gene	Chr17:63798970-63803607 (-)
WSB/EiJ	MGP_WSBEiJ_G0023249	protein coding gene	Chr17:67828690-67833304 (-)

Human Ortholog

TXNDC2, thioredoxin domain containing 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TXNDC2, thioredoxin domain containing 2
Synonyms

SPTRX, SPTRX1
Links

HGNC:16470

NCBI Gene ID: 84203

neXtProt AC: NX_Q86VQ3

UniProt: Q86VQ3
Chr Location

18p11.22; chr18:9885766-9889275 (+) GRCh38

MGI Vertebrate Homology

Txndc2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TXNDC2
Gene Tree

Txndc2

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

5
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene displays normal reproductive system phenotype while results in increased body size, increased serum phosphorus level and decreased serum IL-6 response to LPS challenge.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

16
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

10
UniProt

3
CCDS

CCDS50165.1, CCDS89136.1

Ensembl

ENSMUSG00000050612 (Evidence)
NCBI Gene

213272

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050612	Ensembl Gene Model \| MGI Sequence Detail	4662	C57BL/6J	± kb
transcript	ENSMUST00000050236	Ensembl \| MGI Sequence Detail	1861	Not Applicable
polypeptide	ENSMUSP00000054909	Ensembl \| MGI Sequence Detail	550	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016860 thioredoxin domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR013766 Thioredoxin domain

IPR050620 Thioredoxin-like

IPR036249 Thioredoxin-like superfamily

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All nucleic 17

cDNA 17

Microarray probesets 2

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MGI:2146989

Summaries

All 27

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Txndc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149065	Chr17:65950932-65950962 (-)	-1,784 bp
Tssr149064	Chr17:65949207-65949218 (-)	-50 bp
Tssr149063	Chr17:65949183-65949201 (-)	-29 bp
Tssr149062	Chr17:65949154-65949177 (-)	-3 bp
Tssr5189	Chr17:65949140-65949147 (-)	19 bp
Tssr149061	Chr17:65946817-65946834 (-)	2,337 bp
Tssr149060	Chr17:65946802-65946812 (-)	2,356 bp
Tssr149059	Chr17:65946781-65946794 (-)	2,375 bp
Tssr149058	Chr17:65945941-65945945 (-)	3,220 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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