B3gat2 MGI Mouse Gene Detail - MGI:2389490 - beta-1,3-glucuronyltransferase 2

Symbol

B3gat2
Name

beta-1,3-glucuronyltransferase 2
Synonyms

GlcAT-S

Feature Type

protein coding gene
IDs

MGI:2389490
NCBI Gene: 280645
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:23801007-23886946 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 9.75 cM, cytoband A4-B
Mapping Data

2 experiments

SNPs within 2kb

2790 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2389490	protein coding gene	Chr1:23800834-23888239 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015885	protein coding gene	Chr1:21573336-21674017 (+)
A/J	MGP_AJ_G0015866	protein coding gene	Chr1:21162711-21244245 (+)
AKR/J	MGP_AKRJ_G0015823	protein coding gene	Chr1:21370489-21459317 (+)
BALB/cJ	MGP_BALBcJ_G0015822	protein coding gene	Chr1:20895293-20982895 (+)
C3H/HeJ	MGP_C3HHeJ_G0015656	protein coding gene	Chr1:21382747-21465434 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016276	protein coding gene	Chr1:22547772-22641185 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013995	protein coding gene	Chr1:19244467-19322615 (+)
CAST/EiJ	MGP_CASTEiJ_G0015235	protein coding gene	Chr1:21486901-21574798 (+)
CBA/J	MGP_CBAJ_G0015628	protein coding gene	Chr1:23111945-23187924 (+)
DBA/2J	MGP_DBA2J_G0015727	protein coding gene	Chr1:20647499-20729702 (+)
FVB/NJ	MGP_FVBNJ_G0015731	protein coding gene	Chr1:20420363-20499283 (+)
LP/J	MGP_LPJ_G0015799	protein coding gene	Chr1:21791254-21873058 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015751	protein coding gene	Chr1:24113290-24205597 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016323	protein coding gene	Chr1:21271604-21355784 (+)
PWK/PhJ	MGP_PWKPhJ_G0015018	protein coding gene	Chr1:20410267-20497085 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014799	protein coding gene	Chr1:21386101-21476662 (+)
WSB/EiJ	MGP_WSBEiJ_G0015298	protein coding gene	Chr1:21218092-21302066 (+)

Human Ortholog

B3GAT2, beta-1,3-glucuronyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

B3GAT2, beta-1,3-glucuronyltransferase 2
Synonyms

GLCATS
Links

HGNC:922

NCBI Gene ID: 135152

neXtProt AC: NX_Q9NPZ5

UniProt: Q9NPZ5
Chr Location

6q13

MGI Vertebrate Homology

B3gat2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: B3GAT2
Gene Tree

B3gat2

Diseases

2 with human B3GAT2 associations

				Human Disease	Mouse Models
				Barrett's esophagus IDs Barrett's esophagus DOID:9206 EFO:0000280 ICD10CM:K22.7 ICD9CM:530.85 MESH:D001471 NCI:C2891 OMIM:614266 UMLS_CUI:C0004763
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
7 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

4
Genomic Mutations

1 involving B3gat2
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available

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All GO Annotations

12
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

818
Tissues

106
cDNA Data

7
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA B3GAT2

Xenbase b3gat2

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All Sequences

43
RefSeq

2
UniProt

4
CCDS

CCDS14850.1

Ensembl

ENSMUSG00000026156 (Evidence)
NCBI Gene

280645

			Length	Strain/Species	Flank
genomic	280645	NCBI Gene Model \| MGI Sequence Detail	85940	C57BL/6J	± kb
transcript	NM_172124	RefSeq \| MGI Sequence Detail	4367	Not Specified
polypeptide	P59270	UniProt \| EBI \| MGI Sequence Detail	324	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004589 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

(term hierarchy)
EC

2.4.1.135
InterPro Domains

IPR005027 Glycosyl transferase, family 43

IPR029044 Nucleotide-diphospho-sugar transferases
GlyGen

P59270 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 9

cDNA 7

Primer pair 2

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 7
Earliest

J:324198 Shimoda Y, et al., Cloning and expression of a novel galactoside beta1, 3-glucuronyltransferase involved in the biosynthesis of HNK-1 epitope. J Biol Chem. 1999 Jun 11;274(24):17115-22
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for B3gat2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6095	Chr1:23800830-23800840 (+)	-172 bp
Tssr6096	Chr1:23800868-23800888 (+)	-129 bp
Tssr6097	Chr1:23800889-23800911 (+)	-107 bp
Tssr6098	Chr1:23800927-23800947 (+)	-70 bp
Tssr6099	Chr1:23801057-23801080 (+)	62 bp
Tssr6100	Chr1:23801084-23801099 (+)	85 bp
Tssr6101	Chr1:23812340-23812344 (+)	11,335 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24