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Nod2 Gene Detail
Summary
  • Symbol
    Nod2
  • Name
    nucleotide-binding oligomerization domain containing 2
  • Synonyms
    Card15, F830032C23Rik, Nlrc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429397
    NCBI Gene: 257632
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:89373943-89415102 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 43.51 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429397
 protein coding gene Chr8:89373943-89415103 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033922
 protein coding gene Chr8:89739101-89787162 (+)
A/J MGP_AJ_G0033905
 protein coding gene Chr8:86213387-86261508 (+)
AKR/J MGP_AKRJ_G0033831
 protein coding gene Chr8:88754065-88795679 (+)
BALB/cJ MGP_BALBcJ_G0033898
 protein coding gene Chr8:86371330-86412157 (+)
C3H/HeJ MGP_C3HHeJ_G0033608
 protein coding gene Chr8:89350488-89391995 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034418
 protein coding gene Chr8:93122130-93166670 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031360
 protein coding gene Chr8:80179619-80220391 (+)
CAST/EiJ MGP_CASTEiJ_G0032939
 protein coding gene Chr8:88795122-88840070 (+)
CBA/J MGP_CBAJ_G0033584
 protein coding gene Chr8:96268019-96314109 (+)
DBA/2J MGP_DBA2J_G0033737
 protein coding gene Chr8:85800999-85842160 (+)
FVB/NJ MGP_FVBNJ_G0033684
 protein coding gene Chr8:84765043-84805773 (+)
LP/J MGP_LPJ_G0033829
 protein coding gene Chr8:89857786-89898288 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033727
 protein coding gene Chr8:98722838-98764794 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034437
 protein coding gene Chr8:88761720-88803754 (+)
PWK/PhJ MGP_PWKPhJ_G0032642
 protein coding gene Chr8:85074294-85115774 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032478
 protein coding gene Chr8:87567208-87613492 (+)
WSB/EiJ MGP_WSBEiJ_G0033050
 protein coding gene Chr8:89215025-89255888 (+)



Homology
more
  • Human Ortholog
    NOD2, nucleotide binding oligomerization domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOD2, nucleotide binding oligomerization domain containing 2
  • Synonyms
    ACUG, BLAU, BLAUS, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, YAOS
  • Links
    NCBI Gene ID: 64127
    neXtProt AC: NX_Q9HC29
    UniProt: Q9HC29

  • Chr Location
    16q12.1
Human Diseases
more
  • Diseases
    1 with Nod2 mouse models; 26 with human NOD2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 7 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    235 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology and increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    231
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055994 Ensembl Gene Model | MGI Sequence Detail 41160 C57BL/6J ±  kb
    transcript ENSMUST00000054324 Ensembl | MGI Sequence Detail 4719 Not Applicable  
    polypeptide ENSMUSP00000050538 Ensembl | MGI Sequence Detail 1035 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000011306 nucleotide-binding oligomerization domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR001315 CARD domain
      IPR011029 Death-like domain superfamily
      IPR018228 Deoxyribonuclease, TatD-related, conserved site
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
      IPR007111 NACHT nucleoside triphosphatase
      IPR041075 NOD2, winged helix domain
      IPR051261 NOD-like receptor (NLR)
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2443828
    References
    more
    • Summaries
      All 331
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 38
      Phenotypes 235
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory