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Adam1b Gene Detail
Summary
  • Symbol
    Adam1b
  • Name
    a disintegrin and metallopeptidase domain 1b
  • Synonyms
    fertilin alpha, Ftna, PH-30 alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429506
    NCBI Gene: 280667
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121638161-121641498 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 61.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429506
 protein coding gene Chr5:121638159-121641498 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030029
 protein coding gene Chr5:124990371-124995760 (-)
A/J MGP_AJ_G0029994
 protein coding gene Chr5:119842345-119846511 (-)
AKR/J MGP_AKRJ_G0029931
 protein coding gene Chr5:123720318-123723655 (-)
BALB/cJ MGP_BALBcJ_G0030005
 protein coding gene Chr5:121224039-121228329 (-)
C3H/HeJ MGP_C3HHeJ_G0029723
 protein coding gene Chr5:124287722-124291059 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030458
 protein coding gene Chr5:129746831-129750284 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027684
 protein coding gene Chr5:114518639-114521979 (-)
CAST/EiJ MGP_CASTEiJ_G0029131
 protein coding gene Chr5:123395875-123399025 (-)
CBA/J MGP_CBAJ_G0029692
 protein coding gene Chr5:134854310-134857647 (-)
DBA/2J MGP_DBA2J_G0029842
 protein coding gene Chr5:119913427-119915881 (-)
FVB/NJ MGP_FVBNJ_G0029799
 protein coding gene Chr5:118863590-118866715 (-)
LP/J MGP_LPJ_G0029931
 protein coding gene Chr5:125502144-125506552 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029829
 protein coding gene Chr5:138705378-138708376 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030499
 protein coding gene Chr5:123241151-123244488 (-)
PWK/PhJ MGP_PWKPhJ_G0028845
 protein coding gene Chr5:118684649-118688891 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028682
 protein coding gene Chr5:120998212-121001996 (-)
WSB/EiJ MGP_WSBEiJ_G0029206
 protein coding gene Chr5:123889320-123894481 (-)



Homology
more
  • Human Ortholog
    ADAM1B, ADAM metallopeptidase domain 1B (pseudogene)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM1B, ADAM metallopeptidase domain 1B (pseudogene)
  • Links
    NCBI Gene ID: 100420505

  • Chr Location
    chr12:111927018-111929017 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Adam1b
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    25 strains or lines available
Mice homozygous for a knock-out allele are viable, healthy and fertile with no significant defects in sperm function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062438 Ensembl Gene Model | MGI Sequence Detail 3338 C57BL/6J ±  kb
transcript ENSMUST00000079368 Ensembl | MGI Sequence Detail 3338 Not Applicable  
polypeptide ENSMUSP00000078343 Ensembl | MGI Sequence Detail 806 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 3
    cDNA 11

    Microarray probesets 5
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory