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Dock1 Gene Detail
Summary
  • Symbol
    Dock1
  • Name
    dedicator of cytokinesis 1
  • Synonyms
    9130006G06Rik, b2b3190Clo, D630004B07Rik, Dock180
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429765
    NCBI Gene: 330662
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:134272416-134775376 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 79.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429765
 protein coding gene Chr7:134272383-134775376 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033129
 protein coding gene Chr7:139480545-140011522 (+)
A/J MGP_AJ_G0033111
 protein coding gene Chr7:135600294-136114941 (+)
AKR/J MGP_AKRJ_G0033043
 protein coding gene Chr7:139221873-139745691 (+)
BALB/cJ MGP_BALBcJ_G0033112
 protein coding gene Chr7:135330954-135845197 (+)
C3H/HeJ MGP_C3HHeJ_G0032826
 protein coding gene Chr7:139075802-139614035 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033623
 protein coding gene Chr7:144777516-145308190 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030596
 protein coding gene Chr7:136852459-137349732 (+)
CAST/EiJ MGP_CASTEiJ_G0032156
 protein coding gene Chr7:131005743-131715150 (+)
CBA/J MGP_CBAJ_G0032799
 protein coding gene Chr7:149633601-150190873 (+)
DBA/2J MGP_DBA2J_G0032951
 protein coding gene Chr7:133603895-134111105 (+)
FVB/NJ MGP_FVBNJ_G0032904
 protein coding gene Chr7:133456324-133963928 (+)
LP/J MGP_LPJ_G0033045
 protein coding gene Chr7:141019663-141546449 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032936
 protein coding gene Chr7:150524674-151055777 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033643
 protein coding gene Chr7:138256789-138778805 (+)
PWK/PhJ MGP_PWKPhJ_G0031862
 protein coding gene Chr7:126639856-127225765 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031708
 protein coding gene Chr7:125034364-125617226 (+)
WSB/EiJ MGP_WSBEiJ_G0032267
 protein coding gene Chr7:139129782-139646125 (+)



Homology
more
  • Human Ortholog
    DOCK1, dedicator of cytokinesis 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOCK1, dedicator of cytokinesis 1
  • Synonyms
    ced5, DOCK180
  • Links
    NCBI Gene ID: 1793
    neXtProt AC: NX_Q14185
    UniProt: Q14185

  • Chr Location
    10q26.2; chr10:126905409-127452517 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Dock1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    14 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality associated with abnormal muscle development and failure of lungs to inflate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    21
  • cDNA Data
    23
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 330662 NCBI Gene Model | MGI Sequence Detail 502961 C57BL/6J ±  kb
    transcript NM_001033420 RefSeq | MGI Sequence Detail 6815 C57BL/6  
    polypeptide Q8BUR4 UniProt | EBI | MGI Sequence Detail 1865 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1918821, MGI:2142074, MGI:2442765, MGI:5618854
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:326987 Meyer AE, et al., Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML. Leukemia. 2022 Aug;36(8):2032-2041
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory