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Mrgprb2 Gene Detail
Summary
  • Symbol
    Mrgprb2
  • Name
    MAS-related GPR, member B2
  • Synonyms
    4833406I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441674
    NCBI Gene: 243979
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:48200713-48207834 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441674
 protein coding gene Chr7:48200713-48207834 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032292
 protein coding gene Chr7:49171565-49178683 (-)
A/J MGP_AJ_G0032271
 protein coding gene Chr7:48452120-48459257 (-)
AKR/J MGP_AKRJ_G0032207
 protein coding gene Chr7:49621184-49628297 (-)
BALB/cJ MGP_BALBcJ_G0032283
 protein coding gene Chr7:48110340-48117453 (-)
C3H/HeJ MGP_C3HHeJ_G0031996
 protein coding gene Chr7:49979707-49986823 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032776
 protein coding gene Chr7:51430533-51437659 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0031324
 protein coding gene Chr7:41387046-41394004 (-)
CBA/J MGP_CBAJ_G0031961
 protein coding gene Chr7:53188250-53195365 (-)
DBA/2J MGP_DBA2J_G0032118
 protein coding gene Chr7:47674523-47681788 (-)
FVB/NJ MGP_FVBNJ_G0032072
 protein coding gene Chr7:47617137-47624229 (-)
LP/J MGP_LPJ_G0032199
 protein coding gene Chr7:50129151-50136262 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032109
 protein coding gene Chr7:52305278-52317387 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032793
 protein coding gene Chr7:48589560-48596688 (-)
PWK/PhJ MGP_PWKPhJ_G0031044
 protein coding gene Chr7:41026192-41033356 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030885
 protein coding gene Chr7:36746608-36753958 (-)
WSB/EiJ MGP_WSBEiJ_G0031442
 protein coding gene Chr7:49261453-49268497 (-)



Homology
more
  • Human Ortholog
    MRGPRX1, MAS related GPR family member X1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRGPRX1, MAS related GPR family member X1
  • Synonyms
    GPCR, MGRG2, MRGX1, SNSR4
  • Links
    NCBI Gene ID: 259249
    neXtProt AC: NX_Q96LB2
    UniProt: Q96LB2

  • Chr Location
    11p15.1,11; chr11:18933499-18939414 (-)  GRCh38
  • Human Ortholog
    MRGPRX2, MAS related GPR family member X2
  • Synonyms
    MGRG3, MRGX2
  • Links
    NCBI Gene ID: 117194
    neXtProt AC: NX_Q96LB1
    UniProt: Q96LB1

  • Chr Location
    11p15.1; chr11:19054455-19060717 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired mast cell activation and inflammatory response after treatment with compound 48/80.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243979 NCBI Gene Model | MGI Sequence Detail 7122 C57BL/6J ±  kb
    transcript NM_175531 RefSeq | MGI Sequence Detail 2089 C57BL/6  
    polypeptide Q3KNA1 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
      IPR026234 Mas-related G protein-coupled receptor family
    • GlyGen
      Q3KNA1 3 sites
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 50
      Gene Ontology 4
      Phenotypes 27
    • Earliest
      J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
    • Latest
      J:350522 Son H, et al., PACAP38/mast-cell-specific receptor axis mediates repetitive stress-induced headache in mice. J Headache Pain. 2024 May 28;25(1):87
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory