Prepl MGI Mouse Gene Detail - MGI:2441932 - prolyl endopeptidase-like

Symbol

Prepl
Name

prolyl endopeptidase-like
Synonyms

2810457N15Rik, 9530014L06Rik, D030028O16Rik, MGC:7980, mKIAA0436

Feature Type

protein coding gene
IDs

MGI:2441932
NCBI Gene: 213760
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:85370898-85397669 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 55.19 cM
Mapping Data

2 experiments

SNPs within 2kb

814 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441932	protein coding gene	Chr17:85370122-85397702 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024086	protein coding gene	Chr17:88280733-88307427 (-)
A/J	MGP_AJ_G0024045	protein coding gene	Chr17:85460220-85486928 (-)
AKR/J	MGP_AKRJ_G0024014	protein coding gene	Chr17:86866290-86893028 (-)
BALB/cJ	MGP_BALBcJ_G0024046	protein coding gene	Chr17:85309871-85336593 (-)
C3H/HeJ	MGP_C3HHeJ_G0023811	protein coding gene	Chr17:87724775-87751459 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024491	protein coding gene	Chr17:91400502-91428215 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021930	protein coding gene	Chr17:80660234-80687475 (-)
CAST/EiJ	MGP_CASTEiJ_G0023290	protein coding gene	Chr17:88518368-88545313 (-)
CBA/J	MGP_CBAJ_G0023785	protein coding gene	Chr17:95188337-95215031 (-)
DBA/2J	MGP_DBA2J_G0023913	protein coding gene	Chr17:83935839-83963025 (-)
FVB/NJ	MGP_FVBNJ_G0023879	protein coding gene	Chr17:83430320-83456956 (-)
LP/J	MGP_LPJ_G0023997	protein coding gene	Chr17:89047717-89074865 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023907	protein coding gene	Chr17:95214238-95240923 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024536	protein coding gene	Chr17:87354466-87381935 (-)
PWK/PhJ	MGP_PWKPhJ_G0023035	protein coding gene	Chr17:83521090-83548456 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022846	protein coding gene	Chr17:84178926-84371716 (-)
WSB/EiJ	MGP_WSBEiJ_G0023356	protein coding gene	Chr17:88224899-88251640 (-)

Human Ortholog

PREPL, prolyl endopeptidase like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PREPL, prolyl endopeptidase like
Synonyms

CMS22
Links

HGNC:30228

NCBI Gene ID: 9581

neXtProt AC: NX_Q4J6C6

UniProt: Q4J6C6
Chr Location

2p21; chr2:44316281-44361862 (-) GRCh38

MGI Vertebrate Homology

Prepl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PREPL
Gene Tree

Prepl

Diseases

1 with human PREPL associations

				Human Disease	Mouse Models
				congenital myasthenic syndrome 22 IDs congenital myasthenic syndrome 22 DOID:0080587 OMIM:616224

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

7
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired growth and neonatal hypotonia.

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All GO Annotations

16
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

17
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PREPL

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All Sequences

68
RefSeq

10
UniProt

5
CCDS

CCDS29005.1, CCDS50202.1

Ensembl

ENSMUSG00000024127 (Evidence)
NCBI Gene

213760

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024127	Ensembl Gene Model \| MGI Sequence Detail	26772	C57BL/6J	± kb
transcript	ENSMUST00000171795	Ensembl \| MGI Sequence Detail	2734	Not Applicable
polypeptide	ENSMUSP00000130967	Ensembl \| MGI Sequence Detail	725	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013201 prolyl endopeptidase-like

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR023302 Peptidase S9A, N-terminal domain

IPR002470 Peptidase S9A, prolyl oligopeptidase

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain

IPR051543 Serine Peptidase S9A Subfamily

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All nucleic 11

cDNA 11

Microarray probesets 6

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MGI:1914494, MGI:1924646

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349477 Bhalla K, et al., Similar metabolic pathways are affected in both Congenital Myasthenic Syndrome-22 and Prader-Willi Syndrome. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 16;1870(5):167175

TSS for Prepl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149703	Chr17:85397632-85397703 (-)	1 bp
Tssr149702	Chr17:85395971-85396005 (-)	1,681 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24