Adgrl3 MGI Mouse Gene Detail - MGI:2441950 - adhesion G protein-coupled receptor L3

Symbol

Adgrl3
Name

adhesion G protein-coupled receptor L3
Synonyms

5430402I23Rik, D130075K09Rik, LEC3, lectomedin 3, Lphn3, mKIAA0768

Feature Type

protein coding gene
IDs

MGI:2441950
NCBI Gene: 319387
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr5:81167985-81972980 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 42.62 cM
Mapping Data

1 experiment

SNPs within 2kb

21552 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441950	protein coding gene	Chr5:81167600-81980556 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029660	protein coding gene	Chr5:81594703-82425686 (+)
A/J	MGP_AJ_G0029628	protein coding gene	Chr5:78301617-79084566 (+)
AKR/J	MGP_AKRJ_G0029576	protein coding gene	Chr5:80914372-81732773 (+)
BALB/cJ	MGP_BALBcJ_G0029637	protein coding gene	Chr5:79134427-79940513 (+)
C3H/HeJ	MGP_C3HHeJ_G0029360	protein coding gene	Chr5:81406570-82233322 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030091	protein coding gene	Chr5:84915654-85800679 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027333	protein coding gene	Chr5:74469571-75230102 (+)
CAST/EiJ	MGP_CASTEiJ_G0028768	protein coding gene	Chr5:80584701-81406643 (+)
CBA/J	MGP_CBAJ_G0029329	protein coding gene	Chr5:87614490-88520680 (+)
DBA/2J	MGP_DBA2J_G0029474	protein coding gene	Chr5:78441664-79241862 (+)
FVB/NJ	MGP_FVBNJ_G0029435	protein coding gene	Chr5:77520459-78319066 (+)
LP/J	MGP_LPJ_G0029561	protein coding gene	Chr5:81956671-82808002 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029463	protein coding gene	Chr5:91307395-92288856 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030124	protein coding gene	Chr5:80518107-81318695 (+)
PWK/PhJ	MGP_PWKPhJ_G0028492	protein coding gene	Chr5:77451836-78252419 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028326	protein coding gene	Chr5:79835690-80662219 (+)
WSB/EiJ	MGP_WSBEiJ_G0028849	protein coding gene	Chr5:80784507-81613434 (+)

Human Ortholog

ADGRL3, adhesion G protein-coupled receptor L3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRL3, adhesion G protein-coupled receptor L3
Synonyms

CIRL3, CL3, LEC3, LPHN3
Links

HGNC:20974

NCBI Gene ID: 23284

neXtProt AC: NX_Q9HAR2

UniProt: Q9HAR2
Chr Location

4q13.1; chr4:61200326-62078335 (+) GRCh38

MGI Vertebrate Homology

Adgrl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADGRL3
Gene Tree

Adgrl3

Diseases

1 with Adgrl3 mouse models

Human Disease

Mouse Models

attention deficit hyperactivity disorder

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 3 alleles in 3 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

3
Radiation induced

1
Spontaneous

1
Targeted

7
Genomic Mutations

4 involving Adgrl3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

99 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine.

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All GO Annotations

37
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

4
cDNA Data

15
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ADGRL3

Xenbase adgrl3

ZFIN adgrl3.1

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All Sequences

228
RefSeq

116
UniProt

18
CCDS

CCDS39122.1, CCDS84891.1, CCDS84893.1, CCDS84894.1, CCDS84895.1

Ensembl

ENSMUSG00000037605 (Evidence)
NCBI Gene

319387

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037605	Ensembl Gene Model \| MGI Sequence Detail	804996	C57BL/6J	± kb
transcript	ENSMUST00000120673	Ensembl \| MGI Sequence Detail	5178	Not Applicable
polypeptide	ENSMUSP00000113482	Ensembl \| MGI Sequence Detail	1580	Not Applicable

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UniProt

18 Sequences
Protein Ontology

PR:000001235 adhesion G protein-coupled receptor L3

(term hierarchy)
PDB

4RMK, 4RML, 4YEB, 5AFB, 5FTT, 5FTU, 6JBU, 7WY5, 7WY8, 7WYB, 7X10
InterPro Domains

IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain

IPR043159 D-galactoside/L-rhamnose binding SUEL lectin domain superfamily

IPR032471 GAIN domain, N-terminal

IPR046338 GAIN domain superfamily

IPR001879 GPCR, family 2, extracellular hormone receptor domain

IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily

IPR003924 GPCR, family 2, latrophilin

IPR003334 GPCR, family 2, latrophilin, C-terminal

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR017983 GPCR, family 2, secretin-like, conserved site

IPR000203 GPS motif

IPR003112 Olfactomedin-like domain
GlyGen

Q80TS3 12 sites, 11 N-linked glycans (5 sites), 1 O-linked glycan (2 sites)

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All nucleic 15

cDNA 15

Microarray probesets 2

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MGI:1921745

Summaries

All 61

Developmental Gene Expression 4

Diseases 1

Gene Ontology 11

Phenotypes 26
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:348278 Liakath-Ali K, et al., Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development. PLoS Biol. 2024 May;22(5):e3002599

TSS for Adgrl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46799	Chr5:81167563-81167579 (+)	-414 bp
Tssr46800	Chr5:81167581-81167609 (+)	-390 bp
Tssr46801	Chr5:81167904-81167952 (+)	-57 bp
Tssr1519	Chr5:81167975-81167992 (+)	-1 bp
Tssr46802	Chr5:81168593-81168608 (+)	616 bp
Tssr46803	Chr5:81168728-81168739 (+)	749 bp
Tssr46804	Chr5:81168974-81168992 (+)	998 bp
Tssr46805	Chr5:81169057-81169088 (+)	1,088 bp
Tssr46806	Chr5:81169430-81169436 (+)	1,448 bp
Tssr46807	Chr5:81169482-81169493 (+)	1,503 bp
Tssr46808	Chr5:81169589-81169627 (+)	1,623 bp
Tssr46809	Chr5:81191071-81191116 (+)	23,109 bp
Tssr46810	Chr5:81250812-81250817 (+)	82,830 bp
Tssr46811	Chr5:81287993-81287997 (+)	120,010 bp
Tssr46812	Chr5:81565961-81565966 (+)	397,979 bp
Tssr46813	Chr5:81567915-81567917 (+)	399,931 bp
Tssr46814	Chr5:81609087-81609097 (+)	441,107 bp
Tssr46816	Chr5:81704194-81704209 (+)	536,217 bp
Tssr46817	Chr5:81719425-81719429 (+)	551,442 bp
Tssr46818	Chr5:81731056-81731074 (+)	563,080 bp
Tssr46819	Chr5:81942182-81942195 (+)	774,204 bp
Tssr46820	Chr5:81942213-81942224 (+)	774,234 bp
Tssr46821	Chr5:81948582-81948587 (+)	780,600 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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