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Gprasp2 Gene Detail
Summary
  • Symbol
    Gprasp2
  • Name
    G protein-coupled receptor associated sorting protein 2
  • Synonyms
    5330440H13Rik, GASP2, Prpl5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442071
    NCBI Gene: 245607
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:134739786-134745480 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 57.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    12
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442071
 protein coding gene ChrX:134739783-134745480 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0036069
 protein coding gene ChrX:132532188-132583976 (+)
AKR/J MGP_AKRJ_G0035995
 protein coding gene ChrX:136789479-136843638 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0035769
 protein coding gene ChrX:133165840-133175995 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0033410
 protein coding gene ChrX:124614307-124619218 (+)
CAST/EiJ MGP_CASTEiJ_G0035056
 protein coding gene ChrX:114049385-114099619 (+)
CBA/J MGP_CBAJ_G0035743
 protein coding gene ChrX:141213474-141223484 (+)
DBA/2J MGP_DBA2J_G0035899
 protein coding gene ChrX:131875941-131933143 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0035992
 protein coding gene ChrX:134108520-134113276 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0036617
 protein coding gene ChrX:132534660-132540356 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0034579
 protein coding gene ChrX:114725899-114733753 (+)
WSB/EiJ MGP_WSBEiJ_G0035189
 protein coding gene ChrX:130873026-130878430 (+)



Homology
more
  • Human Ortholog
    ARMCX5-GPRASP2, ARMCX5-GPRASP2 readthrough
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARMCX5-GPRASP2, ARMCX5-GPRASP2 readthrough
  • Synonyms
    ARMCX5-GPRASP2-BHLHB9-LINC00630, bHLHb9, GPRASP3, p60TRP
  • Links
    NCBI Gene ID: 100528062
    neXtProt AC: NX_Q96D09
    UniProt: Q6PI77, Q96D09

  • Chr Location
    Xq22.1; chrX:102599348-102908064 (+)  GRCh38
  • Human Ortholog
    GPRASP2, G protein-coupled receptor associated sorting protein 2
  • Synonyms
    DFNX7, GASP2
  • Links
    NCBI Gene ID: 114928
    neXtProt AC: NX_Q96D09
    UniProt: Q96D09

  • Chr Location
    Xq22.1; chrX:102712445-102717733 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Gprasp2 mouse models; 1 with human GPRASP2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele exhibit increased body weight, autism-like behaviors, alterations in hippocampal pyramidal neuron dendrite complexity, spine density and synaptic maturation, impaired glutamatergic transmission, and enhanced hippocampal long-term depression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    14
  • cDNA Data
    47
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 245607 NCBI Gene Model | MGI Sequence Detail 5695 C57BL/6J ±  kb
    transcript NM_001163015 RefSeq | MGI Sequence Detail 3784 ZRU/MplStud  
    polypeptide Q8BUY8 UniProt | EBI | MGI Sequence Detail 826 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:892978
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory