Insyn1 MGI Mouse Gene Detail - MGI:2442108 - inhibitory synaptic factor 1

Symbol

Insyn1
Name

inhibitory synaptic factor 1
Synonyms

6030419C18Rik

Feature Type

protein coding gene
IDs

MGI:2442108
NCBI Gene: 319477
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:58395886-58407063 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 31.79 cM
Mapping Data

1 experiment

SNPs within 2kb

269 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442108	protein coding gene	Chr9:58395886-58407063 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034891	protein coding gene	Chr9:57783717-57795911 (+)
A/J	MGP_AJ_G0034872	protein coding gene	Chr9:55907888-55918997 (+)
AKR/J	MGP_AKRJ_G0034801	protein coding gene	Chr9:57205289-57216398 (+)
BALB/cJ	MGP_BALBcJ_G0034864	protein coding gene	Chr9:55679691-55690805 (+)
C3H/HeJ	MGP_C3HHeJ_G0034574	protein coding gene	Chr9:57689407-57700494 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035383	protein coding gene	Chr9:59395324-59406466 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032294	protein coding gene	Chr9:55180767-55191838 (+)
CAST/EiJ	MGP_CASTEiJ_G0033895	protein coding gene	Chr9:57781402-57793719 (+)
CBA/J	MGP_CBAJ_G0034545	protein coding gene	Chr9:61484096-61497199 (+)
DBA/2J	MGP_DBA2J_G0034704	protein coding gene	Chr9:55758227-55769356 (+)
FVB/NJ	MGP_FVBNJ_G0034646	protein coding gene	Chr9:55000353-55011462 (+)
LP/J	MGP_LPJ_G0034787	protein coding gene	Chr9:58064842-58075949 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034689	protein coding gene	Chr9:62923959-62935076 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035405	protein coding gene	Chr9:57216544-57227641 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0033434	protein coding gene	Chr9:57504567-57515692 (+)
WSB/EiJ	MGP_WSBEiJ_G0034008	protein coding gene	Chr9:57171598-57183547 (+)

Human Ortholog

INSYN1, inhibitory synaptic factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INSYN1, inhibitory synaptic factor 1
Synonyms

C15orf59
Links

HGNC:33753

NCBI Gene ID: 388135

neXtProt AC: NX_Q2T9L4

UniProt: Q2T9L4
Chr Location

15q24.1; chr15:73735458-73753351 (-) GRCh38

MGI Vertebrate Homology

Insyn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: INSYN1
Gene Tree

Insyn1

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

6
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit elevated neuronal firing patterns in the hippocampus and deficits in fear conditioning memory.

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All GO Annotations

13
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase insyn1

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS23243.1

Ensembl

ENSMUSG00000066607 (Evidence)
NCBI Gene

319477

			Length	Strain/Species	Flank
genomic	319477	NCBI Gene Model \| MGI Sequence Detail	11178	C57BL/6J	± kb
transcript	NM_176921	RefSeq \| MGI Sequence Detail	2177	C57BL/6
polypeptide	Q8CD60	UniProt \| EBI \| MGI Sequence Detail	292	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059791 inhibitory synaptic factor 1

(term hierarchy)
InterPro Domains

IPR027997 Protein Largen/Inhibitory synaptic factor 1

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All nucleic 6

Genomic 1

cDNA 5

Microarray probesets 2

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MGI:6162261

Summaries

All 21

Gene Ontology 3

Phenotypes 5
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:284536 Uezu A, et al., Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice. Elife. 2019 Dec 12;8:e50712

TSS for Insyn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85391	Chr9:58395366-58395393 (+)	-506 bp
Tssr85392	Chr9:58395399-58395415 (+)	-479 bp
Tssr85393	Chr9:58395417-58395444 (+)	-455 bp
Tssr85394	Chr9:58395456-58395459 (+)	-428 bp
Tssr85395	Chr9:58395851-58395861 (+)	-30 bp
Tssr85396	Chr9:58396318-58396322 (+)	434 bp
Tssr85397	Chr9:58397100-58397117 (+)	1,223 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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