Cxxc4 MGI Mouse Gene Detail - MGI:2442112

Symbol

Cxxc4
Name

CXXC finger 4
Synonyms

9330210J02Rik, C030003J12Rik, Idax

Feature Type

protein coding gene
IDs

MGI:2442112
NCBI Gene: 319478
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:133942245-133967922 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 62.12 cM
Mapping Data

1 experiment

SNPs within 2kb

657 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442112	protein coding gene	Chr3:133938927-133967924 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027900	protein coding gene	Chr3:137046894-137076124 (+)
A/J	MGP_AJ_G0027858	protein coding gene	Chr3:132243453-132269193 (+)
AKR/J	MGP_AKRJ_G0027823	protein coding gene	Chr3:135727872-135754071 (+)
BALB/cJ	MGP_BALBcJ_G0027871	protein coding gene	Chr3:132094046-132120136 (+)
C3H/HeJ	MGP_C3HHeJ_G0027600	protein coding gene	Chr3:136074773-136100279 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028314	protein coding gene	Chr3:141837622-141864920 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025652	protein coding gene	Chr3:127592402-127618082 (+)
CAST/EiJ	MGP_CASTEiJ_G0027056	protein coding gene	Chr3:135827998-135855482 (+)
CBA/J	MGP_CBAJ_G0027576	protein coding gene	Chr3:146671011-146700192 (+)
DBA/2J	MGP_DBA2J_G0027716	protein coding gene	Chr3:131395865-131422763 (+)
FVB/NJ	MGP_FVBNJ_G0027683	protein coding gene	Chr3:128956946-128983639 (+)
LP/J	MGP_LPJ_G0027826	protein coding gene	Chr3:138533531-138561304 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027714	protein coding gene	Chr3:154709104-154737731 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028372	protein coding gene	Chr3:135293476-135322728 (+)
PWK/PhJ	MGP_PWKPhJ_G0026780	protein coding gene	Chr3:131175506-131201554 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026606	protein coding gene	Chr3:133418396-133441499 (+)
WSB/EiJ	MGP_WSBEiJ_G0027135	protein coding gene	Chr3:136092538-136119778 (+)

Human Ortholog

CXXC4, CXXC finger protein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXXC4, CXXC finger protein 4
Synonyms

IDAX
Links

HGNC:24593

NCBI Gene ID: 80319

UniProt: Q9H2H0
Chr Location

4q24; chr4:104468308-104494901 (-) GRCh38

MGI Vertebrate Homology

Cxxc4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CXXC4
Gene Tree

Cxxc4

less

References

1 with disease annotations

less

Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Cxxc4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1135
Tissues

119
cDNA Data

13
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cxxc4

less

All Sequences

59
RefSeq

16
UniProt

2
CCDS

CCDS17851.2

Ensembl

ENSMUSG00000044365 (Evidence)
NCBI Gene

319478

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044365	Ensembl Gene Model \| MGI Sequence Detail	25678	C57BL/6J	± kb
transcript	ENSMUST00000181904	Ensembl \| MGI Sequence Detail	5694	Not Applicable
polypeptide	ENSMUSP00000138000	Ensembl \| MGI Sequence Detail	366	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000006075 CXXC-type zinc finger protein 4

(term hierarchy)
InterPro Domains

IPR040388 CXXC-type zinc finger protein CXXC4/CXXC5

IPR002857 Zinc finger, CXXC-type

less

All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 6

less

MGI:1932494, MGI:2443991

Summaries

All 40

Developmental Gene Expression 9

Diseases 1

Gene Ontology 6

Phenotypes 9
Earliest

J:67543 Hino S, et al., Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol Cell Biol. 2001 Jan;21(1):330-42
Latest

J:346126 Pappas MP, et al., Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm. Development. 2024 Mar 1;151(5)

TSS for Cxxc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31786	Chr3:133942092-133942134 (+)	-132 bp
Tssr31787	Chr3:133942244-133942261 (+)	8 bp
Tssr31788	Chr3:133942294-133942303 (+)	54 bp
Tssr31789	Chr3:133942346-133942355 (+)	106 bp
Tssr31790	Chr3:133945015-133945040 (+)	2,783 bp
Tssr31791	Chr3:133945047-133945068 (+)	2,813 bp
Tssr31792	Chr3:133965100-133965116 (+)	22,863 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24