Taf5 MGI Mouse Gene Detail - MGI:2442144 - TATA-box binding protein associated factor 5

Symbol

Taf5
Name

TATA-box binding protein associated factor 5
Synonyms

6330528C20Rik

Feature Type

protein coding gene
IDs

MGI:2442144
NCBI Gene: 226182
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr19:47056187-47071918 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 39.19 cM
Mapping Data

2 experiments

SNPs within 2kb

467 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442144	protein coding gene	Chr19:47056185-47071918 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025221	protein coding gene	Chr19:46842565-46858868 (+)
A/J	MGP_AJ_G0025197	protein coding gene	Chr19:44502486-44518247 (+)
AKR/J	MGP_AKRJ_G0025166	protein coding gene	Chr19:45959389-45978088 (+)
BALB/cJ	MGP_BALBcJ_G0025192	protein coding gene	Chr19:44552211-44568476 (+)
C3H/HeJ	MGP_C3HHeJ_G0024952	protein coding gene	Chr19:46139336-46155066 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025635	protein coding gene	Chr19:47966015-47981756 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023049	protein coding gene	Chr19:43746362-43761551 (+)
CAST/EiJ	MGP_CASTEiJ_G0024417	protein coding gene	Chr19:45950022-45966951 (+)
CBA/J	MGP_CBAJ_G0024932	protein coding gene	Chr19:50397577-50417011 (+)
DBA/2J	MGP_DBA2J_G0025064	protein coding gene	Chr19:44315850-44334506 (+)
FVB/NJ	MGP_FVBNJ_G0025025	protein coding gene	Chr19:44106942-44124401 (+)
LP/J	MGP_LPJ_G0025150	protein coding gene	Chr19:46738075-46754483 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025056	protein coding gene	Chr19:49689097-49706307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025693	protein coding gene	Chr19:46077364-46093900 (+)
PWK/PhJ	MGP_PWKPhJ_G0024166	protein coding gene	Chr19:44279750-44296240 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023970	protein coding gene	Chr19:44729480-44747690 (+)
WSB/EiJ	MGP_WSBEiJ_G0024487	protein coding gene	Chr19:46221795-46239533 (+)

Human Ortholog

TAF5, TATA-box binding protein associated factor 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAF5, TATA-box binding protein associated factor 5
Synonyms

TAF2D, TAF(II)100, TAFII-100, TAFII100
Links

HGNC:11539

NCBI Gene ID: 6877

neXtProt AC: NX_Q15542

UniProt: Q15542
Chr Location

10q24.33; chr10:103367966-103389065 (+) GRCh38

MGI Vertebrate Homology

Taf5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAF5
Gene Tree

Taf5

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
1 images
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele arrest before progressing to an egg-cylinder stage and show empty deciduae, failure of embryo implantation, aberrant lineage specification within the inner cell mass, and peri-implantation lethality.

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All GO Annotations

36
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

98
cDNA Data

10
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase taf5

ZFIN taf5

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS29886.1

Ensembl

ENSMUSG00000025049 (Evidence)
NCBI Gene

226182

			Length	Strain/Species	Flank
genomic	226182	NCBI Gene Model \| MGI Sequence Detail	15732	C57BL/6J	± kb
transcript	NM_177342	RefSeq \| MGI Sequence Detail	3258	C57BL/6
polypeptide	Q8C092	UniProt \| EBI \| MGI Sequence Detail	801	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016029 transcription initiation factor TFIID subunit 5

(term hierarchy)
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR006594 LIS1 homology motif

IPR007582 TFIID subunit TAF5, NTD2 domain

IPR037264 TFIID subunit TAF5, NTD2 domain superfamily

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q8C092 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 4

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MGI:2147674

Summaries

All 48

Developmental Gene Expression 10

Gene Ontology 10

Phenotypes 10
Earliest

J:25214 LeDouarin B, et al., The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J. 1995 May 1;14(9):2020-33
Latest

J:348275 He XD, et al., TATA-binding associated factors have distinct roles during early mammalian development. Dev Biol. 2024 Jul;511:53-62

TSS for Taf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156844	Chr19:47056160-47056207 (+)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24