Micos13 MGI Mouse Gene Detail - MGI:2442174 - mitochondrial contact site and cristae organizing system subunit 13

Symbol

Micos13
Name

mitochondrial contact site and cristae organizing system subunit 13
Synonyms

2410015M20Rik, QIL1

Feature Type

protein coding gene
IDs

MGI:2442174
NCBI Gene: 224904
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:56914452-56916771 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.42 cM
Mapping Data

1 experiment

SNPs within 2kb

105 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442174	protein coding gene	Chr17:56914452-56916771 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023930	protein coding gene	Chr17:58310582-58312889 (-)
A/J	MGP_AJ_G0023888	protein coding gene	Chr17:56718475-56720794 (-)
AKR/J	MGP_AKRJ_G0023857	protein coding gene	Chr17:57417084-57419403 (-)
BALB/cJ	MGP_BALBcJ_G0023889	protein coding gene	Chr17:56536549-56538868 (-)
C3H/HeJ	MGP_C3HHeJ_G0023653	protein coding gene	Chr17:58150538-58152857 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024335	protein coding gene	Chr17:60568844-60571163 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021781	protein coding gene	Chr17:53193106-53195421 (-)
CAST/EiJ	MGP_CASTEiJ_G0023135	protein coding gene	Chr17:58428944-58431265 (-)
CBA/J	MGP_CBAJ_G0023629	protein coding gene	Chr17:62942891-62945210 (-)
DBA/2J	MGP_DBA2J_G0023757	protein coding gene	Chr17:55418978-55421297 (-)
FVB/NJ	MGP_FVBNJ_G0023723	protein coding gene	Chr17:54956904-54959211 (-)
LP/J	MGP_LPJ_G0023839	protein coding gene	Chr17:58998666-59000973 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023751	protein coding gene	Chr17:62434064-62436371 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024379	protein coding gene	Chr17:57781365-57783684 (-)
PWK/PhJ	MGP_PWKPhJ_G0022881	protein coding gene	Chr17:54779490-54781925 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022692	protein coding gene	Chr17:54548434-54550707 (-)
WSB/EiJ	MGP_WSBEiJ_G0023201	protein coding gene	Chr17:58392333-58395032 (-)

Human Ortholog

MICOS13, mitochondrial contact site and cristae organizing system subunit 13

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MICOS13, mitochondrial contact site and cristae organizing system subunit 13
Synonyms

C19orf70, MIC12, MIC13, P117, QIL1
Links

HGNC:33702

NCBI Gene ID: 125988

neXtProt AC: NX_Q5XKP0

UniProt: Q5XKP0
Chr Location

19p13.3; chr19:5678421-5680516 (-) GRCh38

MGI Vertebrate Homology

Micos13 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: MICOS13
Gene Tree

Micos13

Diseases

1 with human MICOS13 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 37 IDs combined oxidative phosphorylation deficiency 37 DOID:0111499 OMIM:618329

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Gene trapped

13
Targeted

2
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

15
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

845
Tissues

47
cDNA Data

116
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase micos13

less

All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS28908.1

Ensembl

ENSMUSG00000049760 (Evidence)
NCBI Gene

224904

			Length	Strain/Species	Flank
genomic	224904	NCBI Gene Model \| MGI Sequence Detail	2320	C57BL/6J	± kb
transcript	NM_153152	RefSeq \| MGI Sequence Detail	755	C57BL/6
polypeptide	Q8R404	UniProt \| EBI \| MGI Sequence Detail	119	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000013563 MICOS complex subunit MIC13

(term hierarchy)
InterPro Domains

IPR026769 MICOS complex subunit Mic13
GlyGen

Q8R404 1 site, 1 O-linked glycan (1 site)

less

All nucleic 116

cDNA 116

Microarray probesets 3

less

MGI:6276300

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Micos13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148828	Chr17:56916988-56917005 (-)	-226 bp
Tssr148827	Chr17:56916958-56916971 (-)	-194 bp
Tssr148826	Chr17:56916928-56916939 (-)	-163 bp
Tssr148825	Chr17:56916823-56916834 (-)	-58 bp
Tssr148824	Chr17:56916804-56916819 (-)	-41 bp
Tssr148823	Chr17:56916689-56916715 (-)	69 bp
Tssr148822	Chr17:56916675-56916686 (-)	90 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24