Dusp4 MGI Mouse Gene Detail - MGI:2442191 - dual specificity phosphatase 4

Symbol

Dusp4
Name

dual specificity phosphatase 4
Synonyms

2700078F24Rik, E130306H24Rik, MKP2

Feature Type

protein coding gene
IDs

MGI:2442191
NCBI Gene: 319520
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:35274451-35287048 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 21.16 cM
Mapping Data

2 experiments

SNPs within 2kb

431 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442191	protein coding gene	Chr8:35274448-35289106 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033535	protein coding gene	Chr8:33360084-33372643 (+)
A/J	MGP_AJ_G0033515	protein coding gene	Chr8:32026035-32038578 (+)
AKR/J	MGP_AKRJ_G0033439	protein coding gene	Chr8:33036857-33049443 (+)
BALB/cJ	MGP_BALBcJ_G0033511	protein coding gene	Chr8:32145555-32158116 (+)
C3H/HeJ	MGP_C3HHeJ_G0033223	protein coding gene	Chr8:33372148-33385407 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034027	protein coding gene	Chr8:34640937-34653507 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030976	protein coding gene	Chr8:29019976-29033006 (+)
CAST/EiJ	MGP_CASTEiJ_G0032550	protein coding gene	Chr8:32844332-32856854 (+)
CBA/J	MGP_CBAJ_G0033201	protein coding gene	Chr8:35954317-35966867 (+)
DBA/2J	MGP_DBA2J_G0033354	protein coding gene	Chr8:31995542-32008123 (+)
FVB/NJ	MGP_FVBNJ_G0033299	protein coding gene	Chr8:31664324-31676919 (+)
LP/J	MGP_LPJ_G0033444	protein coding gene	Chr8:33328051-33340553 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033341	protein coding gene	Chr8:35459744-35472292 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034046	protein coding gene	Chr8:33132281-33144876 (+)
PWK/PhJ	MGP_PWKPhJ_G0032261	protein coding gene	Chr8:31546166-31559495 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032092	protein coding gene	Chr8:32402472-32415105 (+)
WSB/EiJ	MGP_WSBEiJ_G0032666	protein coding gene	Chr8:33302559-33315412 (+)

Human Ortholog

DUSP4, dual specificity phosphatase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP4, dual specificity phosphatase 4
Synonyms

HVH2, MKP-2, MKP2, TYP
Links

HGNC:3070

NCBI Gene ID: 1846

neXtProt AC: NX_Q13115

UniProt: Q13115
Chr Location

8p12; chr8:29333064-29350684 (-) GRCh38

MGI Vertebrate Homology

Dusp4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP4
Protein SuperFamily

MAPK_Ptase
Gene Tree

Dusp4

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Phenotype Summary

25 phenotypes from 4 alleles in 4 genetic backgrounds
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

1
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit a decrease in B cell apoptosis of bone marrow-derived, IL-7-dependent pro-B lymphocytes.

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All GO Annotations

39
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

62
cDNA Data

9
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp4

ZFIN dusp4

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All Sequences

42
RefSeq

4
UniProt

2
CCDS

CCDS22241.1

Ensembl

ENSMUSG00000031530 (Evidence)
NCBI Gene

319520

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031530	Ensembl Gene Model \| MGI Sequence Detail	12598	C57BL/6J	± kb
transcript	ENSMUST00000033930	Ensembl \| MGI Sequence Detail	2740	Not Applicable
polypeptide	ENSMUSP00000033930	Ensembl \| MGI Sequence Detail	398	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006754 dual specificity protein phosphatase 4

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR008343 Mitogen-activated protein (MAP) kinase phosphatase

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 11

cDNA 9

Primer pair 1

Other 1

Microarray probesets 3

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MGI:1917486, MGI:2142625, MGI:2142829

Summaries

All 90

Developmental Gene Expression 23

Gene Ontology 8

Phenotypes 31
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:355651 El Azhar Y, et al., Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking. Development. 2024 Sep 15;151(18):dev202936

TSS for Dusp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76880	Chr8:35274441-35274464 (+)	2 bp
Tssr76881	Chr8:35274468-35274504 (+)	35 bp
Tssr76882	Chr8:35274767-35274769 (+)	317 bp
Tssr76883	Chr8:35276686-35276689 (+)	2,237 bp
Tssr76884	Chr8:35282540-35282553 (+)	8,096 bp
Tssr76885	Chr8:35285809-35285831 (+)	11,369 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24