Map9 MGI Mouse Gene Detail - MGI:2442208 - microtubule-associated protein 9

Symbol

Map9
Name

microtubule-associated protein 9
Synonyms

5033421J10Rik, 5330427D05Rik, ASAP, Mtap9

Feature Type

protein coding gene
IDs

MGI:2442208
NCBI Gene: 213582
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr3:82265379-82302575 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 36.37 cM
Mapping Data

1 experiment

SNPs within 2kb

1453 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442208	protein coding gene	Chr3:82265351-82302575 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027327	protein coding gene	Chr3:82163248-82203429 (+)
A/J	MGP_AJ_G0027289	protein coding gene	Chr3:79454317-79491661 (+)
AKR/J	MGP_AKRJ_G0027257	protein coding gene	Chr3:81332754-81372029 (+)
BALB/cJ	MGP_BALBcJ_G0027300	protein coding gene	Chr3:79546457-79582311 (+)
C3H/HeJ	MGP_C3HHeJ_G0027044	protein coding gene	Chr3:81615465-81651976 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027746	protein coding gene	Chr3:85267489-85310832 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025099	protein coding gene	Chr3:75208846-75245949 (+)
CAST/EiJ	MGP_CASTEiJ_G0026491	protein coding gene	Chr3:81808214-81844536 (+)
CBA/J	MGP_CBAJ_G0027019	protein coding gene	Chr3:88141140-88179280 (+)
DBA/2J	MGP_DBA2J_G0027155	protein coding gene	Chr3:79006362-79041736 (+)
FVB/NJ	MGP_FVBNJ_G0027123	protein coding gene	Chr3:77294129-77329167 (+)
LP/J	MGP_LPJ_G0027263	protein coding gene	Chr3:83159132-83197886 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027142	protein coding gene	Chr3:94516133-94554186 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027804	protein coding gene	Chr3:81135630-81174197 (+)
PWK/PhJ	MGP_PWKPhJ_G0026225	protein coding gene	Chr3:78744786-78782393 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026041	protein coding gene	Chr3:80326746-80401002 (+)
WSB/EiJ	MGP_WSBEiJ_G0026569	protein coding gene	Chr3:81474233-81511484 (+)

Human Ortholog

MAP9, microtubule associated protein 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP9, microtubule associated protein 9
Synonyms

ASAP
Links

HGNC:26118

NCBI Gene ID: 79884

neXtProt AC: NX_Q49MG5

UniProt: Q49MG5
Chr Location

4q32.1; chr4:155342658-155376970 (-) GRCh38

MGI Vertebrate Homology

Map9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP9
Gene Tree

Map9

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Map9
Incidental Mutations

APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous or heterozygous for a null allele exhibit increased aneuploidy, chromosomal instability, detached centrosomes and pericentriolar material fragmentation in MEFs.

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All GO Annotations

26
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

56

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map9

ZFIN map9

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All Sequences

61
RefSeq

8
UniProt

5
CCDS

CCDS38461.1

Ensembl

ENSMUSG00000033900 (Evidence)
NCBI Gene

213582

			Length	Strain/Species	Flank
genomic	213582	NCBI Gene Model \| MGI Sequence Detail	37197	C57BL/6J	± kb
transcript	NM_001081230	RefSeq \| MGI Sequence Detail	6218	Not Specified
polypeptide	Q3TRR0	UniProt \| EBI \| MGI Sequence Detail	646	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010150 microtubule-associated protein 9

(term hierarchy)
InterPro Domains

IPR026106 Microtubule-associated protein 9

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All nucleic 56

cDNA 56

Microarray probesets 4

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MGI:1923244

Summaries

All 34

Diseases 1

Gene Ontology 6

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:299895 Wang S, et al., MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer. Clin Cancer Res. 2020 Feb 1;26(3):746-757

TSS for Map9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29629	Chr3:82265363-82265382 (+)	-6 bp
Tssr29630	Chr3:82265407-82265418 (+)	34 bp
Tssr29631	Chr3:82265440-82265472 (+)	77 bp
Tssr29632	Chr3:82265474-82265492 (+)	104 bp
Tssr29633	Chr3:82265496-82265507 (+)	123 bp
Tssr29634	Chr3:82265512-82265520 (+)	137 bp
Tssr914	Chr3:82265522-82265527 (+)	146 bp
Tssr29635	Chr3:82277864-82277865 (+)	12,486 bp
Tssr29636	Chr3:82287461-82287478 (+)	22,091 bp
Tssr29637	Chr3:82287494-82287514 (+)	22,125 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24