Zfp750 MGI Mouse Gene Detail - MGI:2442210

Symbol

Zfp750
Name

zinc finger protein 750
Synonyms

A030007D23Rik

Feature Type

protein coding gene
IDs

MGI:2442210
NCBI Gene: 319530
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:121401804-121410159 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 85.49 cM
Mapping Data

2 experiments

SNPs within 2kb

148 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442210	protein coding gene	Chr11:121401802-121410168 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019551	protein coding gene	Chr11:126061528-126069883 (-)
A/J	MGP_AJ_G0019518	protein coding gene	Chr11:120417294-120425644 (-)
AKR/J	MGP_AKRJ_G0019488	protein coding gene	Chr11:124076297-124084649 (-)
BALB/cJ	MGP_BALBcJ_G0019493	protein coding gene	Chr11:120797154-120805550 (-)
C3H/HeJ	MGP_C3HHeJ_G0019299	protein coding gene	Chr11:124403616-124411971 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019942	protein coding gene	Chr11:129882676-129891032 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017567	protein coding gene	Chr11:117408494-117416812 (-)
CAST/EiJ	MGP_CASTEiJ_G0018853	protein coding gene	Chr11:125891156-125899527 (-)
CBA/J	MGP_CBAJ_G0019270	protein coding gene	Chr11:134921865-134930217 (-)
DBA/2J	MGP_DBA2J_G0019383	protein coding gene	Chr11:119806544-119814968 (-)
FVB/NJ	MGP_FVBNJ_G0019374	protein coding gene	Chr11:119529521-119538269 (-)
LP/J	MGP_LPJ_G0019454	protein coding gene	Chr11:126340439-126348789 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019407	protein coding gene	Chr11:133720306-133729404 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019981	protein coding gene	Chr11:124763834-124772186 (-)
PWK/PhJ	MGP_PWKPhJ_G0018620	protein coding gene	Chr11:121238076-121246550 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018411	protein coding gene	Chr11:124509791-124518095 (-)
WSB/EiJ	MGP_WSBEiJ_G0018906	protein coding gene	Chr11:124728834-124738323 (-)

Human Ortholog

ZNF750, zinc finger protein 750

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF750, zinc finger protein 750
Synonyms

SLDPE, ZFP750
Links

HGNC:25843

NCBI Gene ID: 79755

neXtProt AC: NX_Q32MQ0

UniProt: Q32MQ0
Chr Location

17q25.3; chr17:82829434-82840022 (-) GRCh38

MGI Vertebrate Homology

Zfp750 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF750
Gene Tree

Zfp750

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Phenotype Summary

29 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele die shortly after birth with absent eyelids and exhibit shiny, wrinkled skin, dehydration, weight loss, thin epidermis, impaired skin barrier function, and alterations in epidermal terminal differentiation and lipid composition.

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

936
Tissues

47
cDNA Data

28
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN znf750

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS25779.1

Ensembl

ENSMUSG00000039238 (Evidence)
NCBI Gene

319530

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039238	Ensembl Gene Model \| MGI Sequence Detail	8356	C57BL/6J	± kb
transcript	ENSMUST00000092298	Ensembl \| MGI Sequence Detail	3232	Not Applicable
polypeptide	ENSMUSP00000089951	Ensembl \| MGI Sequence Detail	703	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000018126 zinc finger protein 750

(term hierarchy)
InterPro Domains

IPR039363 Zinc finger protein 750

IPR039064 Zinc finger protein 750-like, zinc finger

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All nucleic 30

cDNA 28

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:341642 Schwartz B, et al., ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways. J Invest Dermatol. 2023 Sep 3;

TSS for Zfp750:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112463	Chr11:121410627-121410636 (-)	-473 bp
Tssr112462	Chr11:121410599-121410620 (-)	-451 bp
Tssr112461	Chr11:121410152-121410167 (-)	-1 bp
Tssr112460	Chr11:121410123-121410137 (-)	29 bp
Tssr112459	Chr11:121410106-121410121 (-)	45 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24