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Gsap Gene Detail
Summary
  • Symbol
    Gsap
  • Name
    gamma-secretase activating protein
  • Synonyms
    A530088I07Rik, Pion
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442259
    NCBI Gene: 212167
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:21391253-21520130 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 9.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3923 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442259
 protein coding gene Chr5:21380767-21520130 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029314
 protein coding gene Chr5:18725754-18861787 (+)
A/J MGP_AJ_G0029279
 protein coding gene Chr5:18130359-18255969 (+)
AKR/J MGP_AKRJ_G0029230
 protein coding gene Chr5:18813107-18945846 (+)
BALB/cJ MGP_BALBcJ_G0029291
 protein coding gene Chr5:18563844-18696357 (+)
C3H/HeJ MGP_C3HHeJ_G0029010
 protein coding gene Chr5:18883834-19018118 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029744
 protein coding gene Chr5:20115905-20252441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026983
 protein coding gene Chr5:16196730-16320031 (+)
CAST/EiJ MGP_CASTEiJ_G0028422
 protein coding gene Chr5:18204581-18332052 (+)
CBA/J MGP_CBAJ_G0028977
 protein coding gene Chr5:20319077-20464684 (+)
DBA/2J MGP_DBA2J_G0029129
 protein coding gene Chr5:18407889-18530501 (+)
FVB/NJ MGP_FVBNJ_G0029087
 protein coding gene Chr5:17817418-17948057 (+)
LP/J MGP_LPJ_G0029213
 protein coding gene Chr5:19139013-19270071 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029115
 protein coding gene Chr5:21636425-21766302 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029777
 protein coding gene Chr5:18472365-18611753 (+)
PWK/PhJ MGP_PWKPhJ_G0028145
 protein coding gene Chr5:17464700-17586846 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027978
 protein coding gene Chr5:17835317-17966516 (+)
WSB/EiJ MGP_WSBEiJ_G0028502
 protein coding gene Chr5:18526535-18663516 (+)



Homology
more
  • Human Ortholog
    GSAP, gamma-secretase activating protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSAP, gamma-secretase activating protein
  • Synonyms
    PION
  • Links
    NCBI Gene ID: 54103
    neXtProt AC: NX_A4D1B5
    UniProt: A4D1B5

  • Chr Location
    7q11.23; chr7:77310751-77416630 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    6
  • cDNA Data
    18
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039934 Ensembl Gene Model | MGI Sequence Detail 128878 C57BL/6J ±  kb
transcript ENSMUST00000036031 Ensembl | MGI Sequence Detail 3745 Not Applicable  
polypeptide ENSMUSP00000043679 Ensembl | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:331150 Xu P, et al., GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J Exp Med. 2021 Aug 2;218(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory