Spx MGI Mouse Gene Detail - MGI:2442262

Symbol

Spx
Name

spexin hormone
Synonyms

B230216G23Rik

Feature Type

protein coding gene
IDs

MGI:2442262
NCBI Gene: 319552
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:142359167-142365456 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 74.03 cM
Mapping Data

1 experiment

SNPs within 2kb

384 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442262	protein coding gene	Chr6:142359114-142365466 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031464	protein coding gene	Chr6:147200967-147208271 (+)
A/J	MGP_AJ_G0031439	protein coding gene	Chr6:141420108-141426396 (+)
AKR/J	MGP_AKRJ_G0031367	protein coding gene	Chr6:145624794-145631097 (+)
BALB/cJ	MGP_BALBcJ_G0031446	protein coding gene	Chr6:141196079-141202370 (+)
C3H/HeJ	MGP_C3HHeJ_G0031168	protein coding gene	Chr6:145669416-145675702 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031908	protein coding gene	Chr6:151241351-151250909 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029032	protein coding gene	Chr6:140258893-140265214 (+)
CAST/EiJ	MGP_CASTEiJ_G0030536	protein coding gene	Chr6:145235389-145241711 (+)
CBA/J	MGP_CBAJ_G0031128	protein coding gene	Chr6:156982593-156988879 (+)
DBA/2J	MGP_DBA2J_G0031285	protein coding gene	Chr6:140234389-140240675 (+)
FVB/NJ	MGP_FVBNJ_G0031236	protein coding gene	Chr6:138997803-139003615 (+)
LP/J	MGP_LPJ_G0031369	protein coding gene	Chr6:147340090-147348753 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031276	protein coding gene	Chr6:160877508-160883332 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031940	protein coding gene	Chr6:145448576-145454862 (+)
PWK/PhJ	MGP_PWKPhJ_G0030263	protein coding gene	Chr6:138728891-138735103 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030087	protein coding gene	Chr6:143646698-143653122 (+)
WSB/EiJ	MGP_WSBEiJ_G0030629	protein coding gene	Chr6:146077795-146083951 (+)

Human Ortholog

SPX, spexin hormone

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPX, spexin hormone
Synonyms

C12orf39, SPX1
Links

HGNC:28139

NCBI Gene ID: 80763

neXtProt AC: NX_Q9BT56

UniProt: Q9BT56
Chr Location

12p12.1; chr12:21526296-21541249 (+) GRCh38

MGI Vertebrate Homology

Spx stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPX
Gene Tree

Spx

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

3
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

36
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

5
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN spx

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS85181.1, CCDS90134.1

Ensembl

ENSMUSG00000071112 (Evidence)
NCBI Gene

319552

			Length	Strain/Species	Flank
genomic	ENSMUSG00000071112	Ensembl Gene Model \| MGI Sequence Detail	6290	C57BL/6J	± kb
transcript	ENSMUST00000126521	Ensembl \| MGI Sequence Detail	357	Not Applicable
polypeptide	ENSMUSP00000118062	Ensembl \| MGI Sequence Detail	118	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000060047 spexin

(term hierarchy)
InterPro Domains

IPR028126 Spexin

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All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7

TSS for Spx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59483	Chr6:142359102-142359117 (+)	-57 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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