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Nwd1 Gene Detail
Summary
  • Symbol
    Nwd1
  • Name
    NACHT and WD repeat domain containing 1
  • Synonyms
    A230063L24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442268
    NCBI Gene: 319555
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:73372865-73443508 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1659 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442268
 protein coding gene Chr8:73372865-73444504 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033788
 protein coding gene Chr8:73136032-73209678 (+)
A/J MGP_AJ_G0033770
 protein coding gene Chr8:70161093-70231155 (+)
AKR/J MGP_AKRJ_G0033697
 protein coding gene Chr8:72260687-72333842 (+)
BALB/cJ MGP_BALBcJ_G0033764
 protein coding gene Chr8:70299191-70368682 (+)
C3H/HeJ MGP_C3HHeJ_G0033473
 protein coding gene Chr8:72873829-72944664 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034284
 protein coding gene Chr8:75897775-75969922 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031225
 protein coding gene Chr8:64682645-64747617 (+)
CAST/EiJ MGP_CASTEiJ_G0032802
 protein coding gene Chr8:72227287-72298904 (+)
CBA/J MGP_CBAJ_G0033452
 protein coding gene Chr8:78616987-78692111 (+)
DBA/2J MGP_DBA2J_G0033606
 protein coding gene Chr8:69906943-69977512 (+)
FVB/NJ MGP_FVBNJ_G0033551
 protein coding gene Chr8:68990814-69060248 (+)
LP/J MGP_LPJ_G0033695
 protein coding gene Chr8:73209547-73285204 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033595
 protein coding gene Chr8:81088431-81163915 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034301
 protein coding gene Chr8:72360679-72429314 (+)
PWK/PhJ MGP_PWKPhJ_G0032508
 protein coding gene Chr8:69171972-69241540 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032346
 protein coding gene Chr8:71246181-71312625 (+)
WSB/EiJ MGP_WSBEiJ_G0032917
 protein coding gene Chr8:72618409-72688638 (+)



Homology
more
  • Human Ortholog
    NWD1, NACHT and WD repeat domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NWD1, NACHT and WD repeat domain containing 1
  • Links
    NCBI Gene ID: 284434
    neXtProt AC: NX_Q149M9
    UniProt: Q149M9

  • Chr Location
    19p13.11; chr19:16719847-16817963 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    88
  • cDNA Data
    9
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 319555 NCBI Gene Model | MGI Sequence Detail 70644 C57BL/6J ±  kb
transcript NM_176940 RefSeq | MGI Sequence Detail 7732 C57BL/6  
polypeptide A6H603 UniProt | EBI | MGI Sequence Detail 1563 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000030916 NACHT domain- and WD repeat-containing protein 1
    (term hierarchy)
  • InterPro Domains
    IPR025139 Domain of unknown function DUF4062
    IPR020472 G-protein beta WD-40 repeat
    IPR043365 NACHT domain- and WD repeat-containing protein 1
    IPR007111 NACHT nucleoside triphosphatase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9
References
more
  • Summaries
    All 25
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory