About   Help   FAQ
Nek11 Gene Detail
Summary
  • Symbol
    Nek11
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 11
  • Synonyms
    4932416N14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442276
    NCBI Gene: 208583
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:105039355-105272723 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 56.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7939 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442276
 protein coding gene Chr9:105039355-105272723 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035213
 protein coding gene Chr9:106885204-107130171 (-)
A/J MGP_AJ_G0035193
 protein coding gene Chr9:103030261-103257733 (-)
AKR/J MGP_AKRJ_G0035125
 protein coding gene Chr9:105602516-105846944 (-)
BALB/cJ MGP_BALBcJ_G0035186
 protein coding gene Chr9:102736600-102961600 (-)
C3H/HeJ MGP_C3HHeJ_G0034896
 protein coding gene Chr9:105994040-106246897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035706
 protein coding gene Chr9:109831707-110087998 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032604
 protein coding gene Chr9:100558609-100785736 (-)
CAST/EiJ MGP_CASTEiJ_G0034208
 protein coding gene Chr9:105876344-106127399 (-)
CBA/J MGP_CBAJ_G0034865
 protein coding gene Chr9:113673768-113925856 (-)
DBA/2J MGP_DBA2J_G0035026
 protein coding gene Chr9:102513144-102743699 (-)
FVB/NJ MGP_FVBNJ_G0034974
 protein coding gene Chr9:101298030-101519666 (-)
LP/J MGP_LPJ_G0035102
 protein coding gene Chr9:107101517-107343792 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035013
 protein coding gene Chr9:115397699-115634125 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035728
 protein coding gene Chr9:105840279-106088376 (-)
PWK/PhJ MGP_PWKPhJ_G0033915
 protein coding gene Chr9:102797555-103031197 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033750
 protein coding gene Chr9:105909890-106147099 (-)
WSB/EiJ MGP_WSBEiJ_G0034328
 protein coding gene Chr9:105710957-105960202 (-)



Homology
more
  • Human Ortholog
    NEK11, NIMA related kinase 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEK11, NIMA related kinase 11
  • Links
    NCBI Gene ID: 79858
    neXtProt AC: NX_Q8NG66
    UniProt: Q8NG66

  • Chr Location
    3q22.1; chr3:131026850-131350465 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    16
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 208583 NCBI Gene Model | MGI Sequence Detail 233369 C57BL/6J ±  kb
    transcript NM_172461 RefSeq | MGI Sequence Detail 2924 C57BL/6  
    polypeptide Q8C0Q4 UniProt | EBI | MGI Sequence Detail 628 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • EC
      2.7.11.1
    • InterPro Domains
      IPR051131 NEK Ser/Thr protein kinase family, NIMA subfamily
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory