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Lingo2 Gene Detail
Summary
  • Symbol
    Lingo2
  • Name
    leucine rich repeat and Ig domain containing 2
  • Synonyms
    B230217C06Rik, LERN3, Lrrn6c
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442298
    NCBI Gene: 242384
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:35706647-36951747 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 17.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33587 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442298
 protein coding gene Chr4:35696778-36951929 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028138
 protein coding gene Chr4:33353585-34657507 (-)
A/J MGP_AJ_G0028096
 protein coding gene Chr4:32112449-33371175 (-)
AKR/J MGP_AKRJ_G0028059
 protein coding gene Chr4:32973506-34254096 (-)
BALB/cJ MGP_BALBcJ_G0028108
 protein coding gene Chr4:32389726-33685817 (-)
C3H/HeJ MGP_C3HHeJ_G0027836
 protein coding gene Chr4:33289227-34602434 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028549
 protein coding gene Chr4:34595966-35997562 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025890
 protein coding gene Chr4:30147798-31309567 (-)
CAST/EiJ MGP_CASTEiJ_G0027292
 protein coding gene Chr4:33080875-34402301 (-)
CBA/J MGP_CBAJ_G0027808
 protein coding gene Chr4:35722038-37165958 (-)
DBA/2J MGP_DBA2J_G0027952
 protein coding gene Chr4:32071805-33316768 (-)
FVB/NJ MGP_FVBNJ_G0027919
 protein coding gene Chr4:31495277-32731774 (-)
LP/J MGP_LPJ_G0028060
 protein coding gene Chr4:33437637-34731233 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027952
 protein coding gene Chr4:38379740-39991100 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028608
 protein coding gene Chr4:33012819-34343041 (-)
PWK/PhJ MGP_PWKPhJ_G0027010
 protein coding gene Chr4:32119834-33364616 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026839
 protein coding gene Chr4:32870222-34135887 (-)
WSB/EiJ MGP_WSBEiJ_G0027368
 protein coding gene Chr4:33002369-34319492 (-)



Homology
more
  • Human Ortholog
    LINGO2, leucine rich repeat and Ig domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LINGO2, leucine rich repeat and Ig domain containing 2
  • Synonyms
    LERN3, LRRN6C
  • Links
    NCBI Gene ID: 158038
    neXtProt AC: NX_Q7L985
    UniProt: Q7L985

  • Chr Location
    9p21.2-p21.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    32
  • cDNA Data
    16
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045083 Ensembl Gene Model | MGI Sequence Detail 1245101 C57BL/6J ±  kb
    transcript ENSMUST00000098151 Ensembl | MGI Sequence Detail 2781 Not Applicable  
    polypeptide ENSMUSP00000095754 Ensembl | MGI Sequence Detail 606 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000030365 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
      (term hierarchy)
    • InterPro Domains
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR001611 Leucine-rich repeat
      IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      Q3URE9 11 sites, 5 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 16
      Primer pair 3
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:357973 Yoshida F, et al., Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons. Transl Psychiatry. 2024 Oct 23;14(1):448
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory