About   Help   FAQ
Zbtb1 Gene Detail
Summary
  • Symbol
    Zbtb1
  • Name
    zinc finger and BTB domain containing 1
  • Synonyms
    C430003J21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442326
    NCBI Gene: 268564
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:76417040-76443724 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 33.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    567 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442326
 protein coding gene Chr12:76416825-76443729 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019857
 protein coding gene Chr12:76482035-76508592 (+)
A/J MGP_AJ_G0019815
 protein coding gene Chr12:73576826-73603542 (+)
AKR/J MGP_AKRJ_G0019790
 protein coding gene Chr12:75804199-75830751 (+)
BALB/cJ MGP_BALBcJ_G0019794
 protein coding gene Chr12:74050527-74077450 (+)
C3H/HeJ MGP_C3HHeJ_G0019600
 protein coding gene Chr12:76262402-76289944 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020246
 protein coding gene Chr12:78824223-78853729 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017864
 protein coding gene Chr12:70908181-70934664 (+)
CAST/EiJ MGP_CASTEiJ_G0019151
 protein coding gene Chr12:71073357-71100979 (+)
CBA/J MGP_CBAJ_G0019570
 protein coding gene Chr12:81872992-81900474 (+)
DBA/2J MGP_DBA2J_G0019686
 protein coding gene Chr12:73425026-73452111 (+)
FVB/NJ MGP_FVBNJ_G0019673
 protein coding gene Chr12:72268624-72295439 (+)
LP/J MGP_LPJ_G0019758
 protein coding gene Chr12:76456774-76484605 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019712
 protein coding gene Chr12:84899356-84921283 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020282
 protein coding gene Chr12:75277267-75303784 (+)
PWK/PhJ MGP_PWKPhJ_G0018917
 protein coding gene Chr12:67797033-67823785 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018711
 protein coding gene Chr12:69796611-69823138 (+)
WSB/EiJ MGP_WSBEiJ_G0019203
 protein coding gene Chr12:75893896-75923859 (+)



Homology
more
  • Human Ortholog
    ZBTB1, zinc finger and BTB domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB1, zinc finger and BTB domain containing 1
  • Synonyms
    ZNF909
  • Links
    NCBI Gene ID: 22890
    neXtProt AC: NX_Q9Y2K1
    UniProt: Q9Y2K1

  • Chr Location
    14q23.3; chr14:64503712-64533693 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU induced mutation exhibit abnormal thymus, B cell, and T cell differentiation, and reduced numbers of T, B, and NK cells in the spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    49
  • cDNA Data
    11
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033454 Ensembl Gene Model | MGI Sequence Detail 26685 C57BL/6J ±  kb
    transcript ENSMUST00000042779 Ensembl | MGI Sequence Detail 12190 Not Applicable  
    polypeptide ENSMUSP00000041955 Ensembl | MGI Sequence Detail 713 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144776
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:308922 Medeiros de Araujo JA, et al., ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Development. 2021 Aug 15;148(16):dev196642
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory