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Peak1 Gene Detail
Summary
  • Symbol
    Peak1
  • Name
    pseudopodium-enriched atypical kinase 1
  • Synonyms
    1110049L02Rik, C230081A13Rik, NKF3 kinase family member
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442366
    NCBI Gene: 244895
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:56108410-56325351 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4434 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442366
 protein coding gene Chr9:56108410-56325972 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034849
 protein coding gene Chr9:55341598-55559888 (-)
A/J MGP_AJ_G0034830
 protein coding gene Chr9:53544089-53762064 (-)
AKR/J MGP_AKRJ_G0034759
 protein coding gene Chr9:54792035-55012829 (-)
BALB/cJ MGP_BALBcJ_G0034822
 protein coding gene Chr9:53332235-53550658 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0035341
 protein coding gene Chr9:56897627-57131544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032252
 protein coding gene Chr9:52896783-53113758 (-)
CAST/EiJ MGP_CASTEiJ_G0033853
 protein coding gene Chr9:55289501-55521763 (-)
CBA/J MGP_CBAJ_G0034503
 protein coding gene Chr9:58851061-59089790 (-)
DBA/2J MGP_DBA2J_G0034662
 protein coding gene Chr9:53440597-53655485 (-)
FVB/NJ MGP_FVBNJ_G0034604
 protein coding gene Chr9:52638211-52853852 (-)
LP/J MGP_LPJ_G0034745
 protein coding gene Chr9:55627878-55844526 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034647
 protein coding gene Chr9:60372918-60613050 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035363
 protein coding gene Chr9:54788576-55011827 (-)
PWK/PhJ MGP_PWKPhJ_G0033558
 protein coding gene Chr9:53444841-53665932 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033392
 protein coding gene Chr9:55075462-55293706 (-)
WSB/EiJ MGP_WSBEiJ_G0033966
 protein coding gene Chr9:54726398-54947024 (-)



Homology
more
  • Human Ortholog
    PEAK1, pseudopodium enriched atypical kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEAK1, pseudopodium enriched atypical kinase 1
  • Synonyms
    SGK269
  • Links
    NCBI Gene ID: 79834
    neXtProt AC: NX_Q9H792
    UniProt: Q9H792

  • Chr Location
    15q24.3; chr15:77100654-77420914 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced angiogenesis in postnatal retina, VEGFA-treated aortas, and transplanted breast cancer cells infected with VEGFA-expressing adenovirus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074305 Ensembl Gene Model | MGI Sequence Detail 216942 C57BL/6J ±  kb
    transcript ENSMUST00000061552 Ensembl | MGI Sequence Detail 6996 Not Applicable  
    polypeptide ENSMUSP00000109901 Ensembl | MGI Sequence Detail 1735 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029132 inactive tyrosine-protein kinase PEAK1
      (term hierarchy)
    • InterPro Domains
      IPR051511 Mitochondrial Quality Control and Scaffold Kinases
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
    • GlyGen
      Q69Z38 5 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916011, MGI:2142963, MGI:3034954
    References
    more
    • Summaries
      All 38
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory