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Tmcc1 Gene Detail
Summary
  • Symbol
    Tmcc1
  • Name
    transmembrane and coiled coil domains 1
  • Synonyms
    3632431M01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442368
    NCBI Gene: 330401
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115995572-116170447 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2846 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442368
 protein coding gene Chr6:115995572-116170485 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031162
 protein coding gene Chr6:118669394-118849868 (-)
A/J MGP_AJ_G0031132
 protein coding gene Chr6:114117118-114295014 (-)
AKR/J MGP_AKRJ_G0031062
 protein coding gene Chr6:117168538-117319973 (-)
BALB/cJ MGP_BALBcJ_G0031142
 protein coding gene Chr6:113925826-114080568 (-)
C3H/HeJ MGP_C3HHeJ_G0030566
 protein coding gene Chr6:66966675-67124448 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031601
 protein coding gene Chr6:121689726-121859775 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028765
 protein coding gene Chr6:111113892-111299450 (-)
CAST/EiJ MGP_CASTEiJ_G0030249
 protein coding gene Chr6:117547452-117740613 (-)
CBA/J MGP_CBAJ_G0030828
 protein coding gene Chr6:126478145-126647585 (-)
DBA/2J MGP_DBA2J_G0030982
 protein coding gene Chr6:113031498-113190436 (-)
FVB/NJ MGP_FVBNJ_G0030935
 protein coding gene Chr6:112220240-112401971 (-)
LP/J MGP_LPJ_G0031061
 protein coding gene Chr6:118672970-118839349 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030970
 protein coding gene Chr6:130628245-130830804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031629
 protein coding gene Chr6:117195803-117359289 (-)
PWK/PhJ MGP_PWKPhJ_G0029965
 protein coding gene Chr6:112052337-112228840 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029793
 protein coding gene Chr6:115962349-116103144 (-)
WSB/EiJ MGP_WSBEiJ_G0030333
 protein coding gene Chr6:117466400-117631530 (-)



Homology
more
  • Human Ortholog
    TMCC1, transmembrane and coiled-coil domain family 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMCC1, transmembrane and coiled-coil domain family 1
  • Links
    NCBI Gene ID: 23023
    neXtProt AC: NX_O94876
    UniProt: O94876

  • Chr Location
    3q22.1; chr3:129647792-129893711 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    17
  • cDNA Data
    16
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030126 Ensembl Gene Model | MGI Sequence Detail 174876 C57BL/6J ±  kb
transcript ENSMUST00000032222 Ensembl | MGI Sequence Detail 2815 Not Applicable  
polypeptide ENSMUSP00000032222 Ensembl | MGI Sequence Detail 690 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000032360 transmembrane and coiled-coil domains protein 1
    (term hierarchy)
  • InterPro Domains
    IPR019394 Testis-specific protein TEX28/transmembrane and coiled-coil domains protein
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:335855 Jo D, et al., Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-kappaB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses. J Neuroinflammation. 2023 May 22;20(1):121
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory