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Ipo11 Gene Detail
Summary
  • Symbol
    Ipo11
  • Name
    importin 11
  • Synonyms
    1700081H05Rik, 2510001A17Rik, E330021B14Rik, Ranbp11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442377
    NCBI Gene: 76582
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:106930947-107073466 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 58.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1317 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442377
 protein coding gene Chr13:106930947-107073466 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020916
 protein coding gene Chr13:108969984-109129658 (-)
A/J MGP_AJ_G0020867
 protein coding gene Chr13:104727756-104876491 (-)
AKR/J MGP_AKRJ_G0020842
 protein coding gene Chr13:107910792-108055434 (-)
BALB/cJ MGP_BALBcJ_G0020867
 protein coding gene Chr13:105433773-105581738 (-)
C3H/HeJ MGP_C3HHeJ_G0020656
 protein coding gene Chr13:107665497-107818797 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021301
 protein coding gene Chr13:112288219-112437717 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018871
 protein coding gene Chr13:100183811-100316584 (-)
CAST/EiJ MGP_CASTEiJ_G0020175
 protein coding gene Chr13:107157135-107312655 (-)
CBA/J MGP_CBAJ_G0020618
 protein coding gene Chr13:116600577-116760026 (-)
DBA/2J MGP_DBA2J_G0020742
 protein coding gene Chr13:104495027-104640955 (-)
FVB/NJ MGP_FVBNJ_G0020724
 protein coding gene Chr13:103153954-103297626 (-)
LP/J MGP_LPJ_G0020816
 protein coding gene Chr13:109046244-109212046 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020752
 protein coding gene Chr13:117070887-117229495 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021340
 protein coding gene Chr13:107331058-107479576 (-)
PWK/PhJ MGP_PWKPhJ_G0019928
 protein coding gene Chr13:103147728-103297382 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019750
 protein coding gene Chr13:103578190-103740679 (-)
WSB/EiJ MGP_WSBEiJ_G0020233
 protein coding gene Chr13:107877852-108037135 (-)



Homology
more
  • Human Ortholog
    IPO11, importin 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IPO11, importin 11
  • Synonyms
    RanBP11
  • Links
    NCBI Gene ID: 51194
    neXtProt AC: NX_Q9UI26
    UniProt: Q9UI26

  • Chr Location
    5q12.1; chr5:62403972-62628582 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    19
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76582 NCBI Gene Model | MGI Sequence Detail 142520 C57BL/6J ±  kb
    transcript NM_001360897 RefSeq | MGI Sequence Detail 4366 C57BL/6  
    polypeptide Q8K2V6 UniProt | EBI | MGI Sequence Detail 975 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920761, MGI:1923832, MGI:2145201, MGI:2145456
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory